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Found 138 clinical trials
Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation (ROAM-DBS)

The purpose of the ROAM-DBS study is to compare the time needed to achieve a 1 point improvement Patient's Global Impression of change (PGIC) relative to the subject's status at the end of the ADROIT initial programming visit in subjects who receive programming updates via in-clinic sessions and subjects who …

brain stimulation
  • 1 views
  • 07 Oct, 2022
  • 16 locations
Trial of Parkinson's And Zoledronic Acid (TOPAZ)

This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will …

supranuclear palsy
Accepts healthy volunteers
atrophy
screening procedures
cognitive assessment
  • 256 views
  • 12 May, 2022
  • 53 locations
A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Breast Cancer (MORPHEUS- BREAST CANCER)

This is a Phase Ib/II, open-label, multicenter, randomized umbrella study in participants with breast cancer. Cohort 1 will focus on participants with inoperable, locally advanced or metastatic, estrogen receptor (ER)-positive, HER2-negative breast cancer who had disease progression during or following treatment with a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i; e.g., palbociclib, …

  • 0 views
  • 28 Oct, 2022
  • 28 locations
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, 76-week Study Evaluating the Safety and Efficacy of Two Doses of Simufilam in Subjects With Mild-to-Moderate Alzheimer's Disease (REFOCUS-ALZ)

A 76-week safety and efficacy study of simufilam (PTI-125) given twice daily to participants with mild-to-moderate Alzheimer's disease (AD) for 76 weeks. Approximately 1083 participants will be randomized (1:1:1) to receive either placebo, 50 mg tablets of simufilam, or 100 mg tablets of simufilam, twice daily, for 76 weeks. Clinic …

mini-mental state examination
alzheimer's disease
dementia
  • 18 views
  • 15 Oct, 2022
  • 64 locations
Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

To evaluate and compare the efficacy of two dosing regimens of oral edaravone in subjects with amyotrophic lateral sclerosis (ALS) based on the change in ALS Functional Rating ScaleRevised (ALSFRS-R) score from baseline up to Week 48:

primary lateral sclerosis
edaravone
  • 1 views
  • 02 Jun, 2022
  • 94 locations
Deep Brain Stimulation Therapy in Movement Disorders

movement. DBS might help people with movement disorders like Parkinson s disease (PD), dystonia, and essential tremor (ET). Objective To provide DBS

movement disorder
primary dystonia
dyskinesia
dopa
intention tremor
  • 265 views
  • 21 Oct, 2022
  • 1 location
Deep Brain Stimulation Surgery for Movement Disorders

Background Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other

movement disorder
primary dystonia
dyskinesia
dopa
blood test
  • 217 views
  • 23 Oct, 2022
  • 1 location
Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's disease (PD) and essential tremor. These

essential tremor
deep brain stimulation
tremor
depression
parkinson's disease
  • 1 views
  • 19 Apr, 2022
  • 1 location
Novel Paradigms of Deep Brain Stimulation for Movement Disorders

Investigators will enroll patients who are already selected to undergo deep brain stimulation surgery based on standard of care. The surgical implantation of the leads will be based on standard of care and will be completed with FDA-approved leads that are routinely used at Cleveland Clinic. The pulse generators (i.e. …

brain stimulation
  • 0 views
  • 21 Oct, 2022
  • 1 location
Neurobiological Studies of Functional Movement Disorders and Non-Epileptic Seizures

disorder. The study is conducted at NIH and at the Brown University Rhode Island Hospital. Healthy volunteers and people with functional movement disorders (FMD) or non-epileptic seizures (NES) who

fahn
seizure
Accepts healthy volunteers
functional movement disorder
tremor
  • 26 views
  • 29 Oct, 2022
  • 1 location