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Found 906 clinical trials
Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.

The hypothesis of a link between depression and Hypothalamic-Pituitary Axis (HPA) dysfunction is now experienced. Since a first description in 1949 this link has made the HPA one of the most investigated hormonal axis in depression. Many studies have demonstrated quantitative variations of circulating cortisol in situation of depression including …

depressive disorder
glucocorticoids
antidepressants
norepinephrine
depressed mood
  • 0 views
  • 25 Jan, 2021
  • 2 locations
Clinical Effectiveness of TARA Compared to Standard Treatment for Adolescents and Young Adults With Depression

Depressive Disorders constitute an increasing global health concern and available treatments for young people have not been sufficiently effective in haltering this trend. The novel group treatment program "Training for Awareness, Resilience, and Action" (TARA) was developed to target specific mechanisms based on neuroscientific findings in adolescent depression. TARA is …

  • 0 views
  • 08 Apr, 2021
  • 6 locations
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

This study proposes to use quetiapine as an adjunct treatment to treatment as usual to improve both substance use disorder (SUD) and mood symptoms in youth with SUD and severe mood dysregulation (SMD). This is a randomized, double blind placebo controlled parallel design study. Youth with symptoms of mood dysregulation …

substance use
quetiapine
mood symptoms
bipolar disorder
mood disorder
  • 93 views
  • 31 Mar, 2021
  • 2 locations
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression

This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression. Even with multiple medication trials, 30 - 40% of patients will experience a pharmacologically resistant form of illness. The ineffectiveness of current treatments for major depressive disorder …

psychosis
depressive disorder
convulsive therapy
remission
major depressive disorder
  • 349 views
  • 26 Jan, 2021
  • 2 locations
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression

The purpose of this study is to assess the impact of music on patients receiving a course of intravenous (IV) ketamine for treatment-resistant depression (TRD), both unipolar and bipolar. The primary outcome is changes in in systolic blood pressure throughout each 40-minute infusion. Secondary outcomes include repeated measures of mood, …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Mindfulness Based Emotion Regulation Therapy in the Treatment of Depressive Rumination

In this study the investigators are examining the neuronal processes of a mindfulness based emotion regulation training for reducing depressive rumination. The research of depressive rumination helps in the developement of new therapies for depressive disorders. Goal of this project is to have a look at the coherences between stress, …

depressive disorder
  • 25 views
  • 26 Jan, 2021
  • 1 location
Mindful Breathing and tDCS for Depression

This study will investigate whether transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex (DLPFC) can enhance the therapeutic effect of mindful breathing training (MBT) for adolescent depression. The objective is to enhance connectivity between the DLPFC with the amygdala and Default Mode Network (DMN) circuits as well as …

depression
depressed mood
dysthymic disorder
depressive symptoms
depressive disorder
  • 86 views
  • 25 Jan, 2021
  • 1 location
The Unified Protocol for the Treatment of Emotional Disorders in Spanish Public Mental Health System

The present randomized, controlled trial will compare the cost-efficacy and acceptability of the Unified Protocol in group format against traditional individual Cognitive Behavioral Treatment in a sample of patients with emotional disorders. Ultimately, the goal of the current study is to explore whether the Unified Protocol in group format can …

anxiety
behavioral therapy
mood disorder
cognitive therapy
behavior therapy
  • 22 views
  • 24 Jan, 2021
  • 5 locations
Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression

Background Some women who had depression in the perimenopause may have mood symptoms again if they stop estrogen therapy. Estrogen acts in the brain and other tissues by binding to at least three types of estrogen receptors. One of these receptors, estrogen receptor beta may affect anxiety and depression. The …

anxiety
antidepressant
probe
scid
mood symptoms
  • 107 views
  • 24 Jan, 2021
  • 1 location
Electronic Communication Augmented Mental Health Care

are evidence-based treatments for these disorders, these disorders often go untreated or under-treated with negative outcomes, particularly suicide in the case of mood disorders. Electronic

anxiety
mood disorder
suicide
psychotherapy
  • 509 views
  • 26 Jan, 2021
  • 1 location