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Found 901 clinical trials
Repetitive Transcranial Magnetic Stimulation for Adolescent Depression: Efficacy Predictive Biomarkers and Mechanisms

This study will be an open-label 6-week (30 session) trial of active repetitive transcranial magnetic stimulation (rTMS) using a fixed frequency (10 Hz) but varying stimulation intensities using a 3+3 study design for safety and tolerability amongst adolescents. This means that we will only enroll 3 participants at a time …

depressive disorder
transcranial magnetic stimulation
  • 113 views
  • 25 Jan, 2021
  • 1 location
Affective Management Training for Cannabis Misuse

Emerging evidence suggests that it is not the negative affect per se but underlying maladaptive cognitive, behavioral, and emotional responses to it that put an individual at risk of pathological substance use. Maladaptive reactivity to negative affect may account for the association between substance-use and emotional disorders and may contribute …

  • 28 views
  • 26 Jan, 2021
  • 2 locations
Ball Blankets on Insomnia in Depression in Outpatient Clinics

The objective of the study is to examine the efficacy of Protac Ball BlanketsTM (PBB) and specifically if the PBB will extend the total sleep time of patients with insomnia due to depression in two psychiatric outpatient clinics at Aarhus University Hospital and Odense University Hospital. Furthermore, it will be …

  • 3 views
  • 23 Jan, 2021
  • 2 locations
Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania: 16-weeks Follow-up With Quetiapine XR

There is sound evidence that quetiapine is effective in the treatment of manic and depressive episodes associated with Bipolar Disorder (BD) (Yatham et al 2006). However, even with the development of effective new treatment options, not all patients respond to treatments available. Biological markers have been investigated as predictors of …

valproic acid
quetiapine
scid
mania
structured clinical interview
  • 39 views
  • 07 Nov, 2020
  • 1 location
The Efficacy of a Cognitive-Behavioural Intervention in Deliberate Self-Harm Patients

The purpose of this study is to evaluate whether the proposed cognitive-behavioural intervention is effective for DSH patients in the age group 15-35 years. In addition, we will examine which elements derived from the theoretical model can explain the efficacy of the intervention.

  • 62 views
  • 07 Nov, 2020
  • 1 location
CBT With VR Based Exposure for Social Anxiety Disorder

Social Anxiety Disorder (SAD) is classified as a phobic (anxious) disorder in which the patient experiences anxiety in social interactions, during which he or she might be judged or socially evaluated by others. SAD has an estimated lifetime prevalence of 3-13%, but remains under-treated. The recommended psychological treatment for SAD …

exposure therapy
cognitive therapy
exposure technique
social interactions
behavioral therapy
  • 0 views
  • 23 Jan, 2021
  • 1 location
Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents

The purpose of this investigation is to test the efficacy of "iDOVE2" (a brief emergency department introductory session and longitudinal automated text-message depression prevention program for high-risk teens), and to determine the most potent and parsimonious combination of intervention components for preventing peer violence and depressive symptoms among at-risk youth.

physical violence
depressed mood
depression
violence
behavioral therapy
  • 8 views
  • 29 Jan, 2021
  • 1 location
Coaching Intervention in Women At-risk of Depressive Disorders

This study aims to provide preventative intervention to more than 500 women who are at risk of depressive disorders in Hong Kong using validated screening tool.

depressed mood
anxiety
depression
depressive symptoms
  • 31 views
  • 23 Jan, 2021
  • 1 location
Message-Based Psychotherapy and Digital Treatment Sequences for Depression

This partnership between Talkspace and the UW ALACRITY Center will determine how effective unlimited text-based psychotherapy for depression is when compared to once-a-week psychotherapy. This study will also determine what the best treatment options are for people who are not responding well to either unlimited texting or weekly psychotherapy. The …

  • 0 views
  • 23 Mar, 2021
  • 1 location
Follow-up Study With Clinical Vitamin D Supplementation Trial on Patients With Depression (DepFuD)

Depression affects 350 million people worldwide. In the light of the global disease burden statistics, the efficacy of current treatments for depression appears insufficient. Thus, research on novel treatment interventions and predictors for good treatment response are warranted. Earlier prospective follow-up studies and intervention studies suggest that several bio-psychosocial factors, …

depressed mood
psychosis
scid
psychiatric disorder
recurrent depression
  • 4 views
  • 23 Jan, 2021
  • 1 location