Found 515 clinical trials
Observatory of Prolymphocytic Leukemia T
response to conventional chemotherapy. Treatment with the anti-CD52 monoclonal antibody: alemtuzumab has considerably improved the results, but the responses to treatment are transient; therefore
- 0 views
- 04 Oct, 2022
- 1 location
Safety of Exposure to Natalizumab During Pregnancy (BABYZUMAB-2)
relapses and the risk of toxicity to the fetus. Natalizumab (NTZ) is a humanized anti-alpha4-integrin monoclonal antibody used as a treatment for highly active relapsing-remitting MS (RRMS). When it
- 0 views
- 03 Sep, 2023
- 19 locations
Small Airways Disease (SAD) in Severe Asthma as a Novel Endpoint and Distinct Target for Biological Therapy. (SASAB)
clinical trials have in recent years demonstrated the efficacy of biologics in severe asthma. Omalizumab, a humanized anti-Imunoglobulin E monoclonal antibody (mAb) has been well recognized as an important
- 0 views
- 11 Apr, 2023
- 1 location
Lanadelumab in Bradykinin Angioedema (KALAN)
A multicenter observational study aiming to evaluate the efficacy of kallikrein inhibition by lanadelumab in patients with bradykinin- angioedema
- 0 views
- 23 Mar, 2022
- 2 locations
Observational Study of the Efficacy and Safety of Anlotinib Combined With Penpulimab in Elderly Lung Cancer Patients (AP)
This prospective observational study will evaluate the efficacy and safety of anlotinib in combination with Penpulimab in elderly patients with lung cancer. Data will be collected from each patient at baseline and after 4-6 cycles of therapy.
- 0 views
- 09 Jun, 2022
- 1 location
Alendronate in an Weekly Effervescent Tablet Formulation Following Denosumab Discontinuation (BAD)
Discontinuation of denosumab results in a rebound response of bone turnover markers, which rise above baseline at 3 months and remain elevated until reaching again baseline levels approximately 30 months after the last dose. Bone mineral density (BMD) gains are also lost and BMD values reach original baseline values after …
- 28 views
- 17 Mar, 2022
- 1 location
Treatment of Hemophilia A Patients With FVIII Inhibitors (MOTIVATE)
This is a non-interventional, multicenter, observational, international study in male persons with haemophilia A who have developed inhibitors to any replacement coagulation factor VIII (FVIII) product. The purpose of the study is to capture different approaches in the management of persons with haemophilia A and FVIII inhibitors, document current immune …
- 42 views
- 23 Aug, 2023
- 1 location
BIOREN (Predictive BIOmarkers in Metastatic RENal Cancer)
The BIOREN project aims are to characterize the genetic background of renal cell carcinomas and their immune environment, to try and identify biomarkers of response and to better understand the mechanisms of resistance to nivolumab in renal cancer.
- 0 views
- 18 Feb, 2021
- 1 location
Clonal Evolution in Follicular Lymphoma
Background Follicular lymphoma is a type of cancer of the lymph nodes. Lab studies are important for cancer research. They help scientists better understand differences in the cancer biology of different patients. Researchers want to collect serial samples over time from people with follicular lymphoma to help them design future …
- 77 views
- 04 Apr, 2023
- 1 location
Gaucherite - A Study to Stratify Gaucher Disease
The purpose of this research is to review data already collected and to collect new data from adults and children in England with Gaucher Disease to determine clinical factors which predict severity and response to therapy of Gaucher disease especially in the areas of bone, cancer and brain conditions.
- 117 views
- 28 Jul, 2021
- 8 locations