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Found 418 clinical trials
Activity and Safety of Lenalidomide and Rituximab (LenRtx) as Non-chemotherapy Based Therapy for Patients With Chronic Lymphocytic Leukemia

) triggered by monoclonal antibodies such as rituximab. Lenalidomide augments NK cytotoxicity by increasing CD56dimCD3 subset, in addition to inducing IL-2 in T cells. These results provide the

monoclonal antibodies
lenalidomide
rituximab
lymphoma
monoclonal protein
  • 18 views
  • 08 Nov, 2020
  • 1 location
Study of VRC07-523LS, CAP256V2LS, and Vesatolimod, in Early Antiretroviral-treated HIV-1 Clade C-infected Women

The primary objective of this study is to evaluate safety and tolerability of dual anti-human immunodeficiency virus (HIV) envelope monoclonal antibodies (mAbs), VRC07-523LS and CAP256V2LS, in a

  • 0 views
  • 04 Oct, 2022
  • 1 location
KETOMIGRAINE: Ketogenic Diet in Drug-resistant Chronic Migraineurs

non-responders to monoclonal antibodies targeting the CGRP pathway. The trial starts with one month of baseline during which are verified inclusion/exclusion criteria. After that, participants will

  • 0 views
  • 27 Apr, 2022
  • 1 location
Nivolumab and ADI-PEG 20 Before Surgery for the Treatment of Resectable Liver Cancer

monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. ADI-PEG 20 may stop the growth of tumor

  • 0 views
  • 04 Oct, 2022
  • 1 location
Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma

can be removed by surgery (surgically accessible). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the

aptt
low grade glioma
tumor cells
karnofsky performance status
international normalized ratio
  • 9 views
  • 19 Apr, 2022
  • 1 location
Neoadjuvant PD-1 Antibody Alone or Combined With DC Vaccines for Recurrent Glioblastoma

overall survival is estimated to rarely exceed 6-9 months with effective therapies. Neoadjuvant therapy with anti-PD-1 monoclonal antibodies were confirmed to be helpful to extend survival in rGBM

  • 0 views
  • 08 Dec, 2021
  • 1 location
Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients With Previously Untreated Metastatic Colorectal Cancer (SOLARIS) (SOLARIS)

in different ways to stop the growth of tumor cells by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as

open biopsy
oxaliplatin
adjuvant therapy
rifampin
platelet count
  • 148 views
  • 12 Oct, 2022
  • 881 locations
Nivolumab and Ipilimumab in Combination With Immunogenic Chemotherapy for Patients With Advanced NSCLC (NSCLC)

metastatic (the cancer has spread) NSCLC. It is a type of drug called a monoclonal antibody (a type of protein). Monoclonal antibodies bind to other proteins, such as PD-1 (programmed cell death-1), on

  • 0 views
  • 01 Mar, 2022
  • 1 location
Rotation or Change of Biotherapy After TNF Blocker Treatment Failure for Axial Spondyloarthritis (ROC-SPA)

rheumatoid arthritis. Etanercept is a fusion protein with TNF receptor type II p75 and IgG1 Fc fragment, whereas adalimumab, infliximab, and golimumab are monoclonal antibodies. Certolizumab is a fusion

certolizumab pegol
tumor necrosis factor
psoriatic arthritis
biological therapy
DMARD
  • 17 views
  • 28 Oct, 2022
  • 13 locations
Isatuximab in Combination With Rd Compared to Rd in Elderly Patients (Aged ≥70 Years) With NDMM

As optimal tolerance is the key for developing new treatments for the very elderly population, the aim of the study is to compare the efficacy and tolerance of isatuximab in combination with lenalidomide+dexamethasone (Rd) versus Rd only in very elderly patients aged 70 years or older. ln sum, a clear …

  • 0 views
  • 07 Oct, 2022
  • 10 locations