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Found 527 clinical trials
featured
  • 198 views
  • 23 Nov, 2020
  • 1 location
featured
  • 208 views
  • 13 Aug, 2020
  • 1 location
featured
A Phase 2a, Double-blind, Randomized, Placebo-controlled, Proof of Concept Study of Vascular Endothelial Growth Factor (VEGF)-B Blockade with the Monoclonal Antibody CSL346 in Subjects with Diabetic Kidney Disease.

We are currently recruiting participants for a clinical research study to evaluate the efficacy of an investigational medication in adults with Diabetic Kidney Disease.

diabetes
kidney function tests
diabetic complication
hemoglobin a1c
diabetic chronic kidney disease
  • 12 views
  • 17 May, 2021
  • 1 location
featured
A Phase 1/1b Study of Sitravatinib in Combination with Nivolumab and Ipilimumab in Patients with Advanced or Metastatic Clear-Cell Renal Cell Carcinoma or Other Solid Malignancies

related RTKs including the TAM family (Tyro3/Axl/MERTK), VEGFR2, KIT, and MET. NIVO/IPI are monoclonal antibodies (mAbs) that inhibit the immune checkpoint proteins programmed death receptor-1 (PD-1

tyrosine
nivolumab
carcinoma
VEGFR2
systemic therapy
  • 27 views
  • 15 Sep, 2020
  • 1 location
featured
A 12-month, Randomized, Rater- and Dose-blinded Study to Compare the Efficacy and Safety of Fingolimod 0.25 mg and 0.5 mg Administered Orally Once Daily With Glatiramer Acetate 20 mg Administered Subcutaneously Once Daily in Patients With Relapsing-remitting Multiple Sclerosis

A 12-month, Randomized, Rater- and Dose-blinded Study to Compare the Efficacy and Safety of Fingolimod 0.25 mg and 0.5 mg Administered Orally Once Daily With Glatiramer Acetate 20 mg Administered Subcutaneously Once Daily in Patients With Relapsing-remitting Multiple Sclerosis

  • 74 views
  • 25 Mar, 2021
  • 1 location
featured
A Phase I, dose-escalation study investigating the safety and tolerability of intratumoral injection of an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) in patients with cancer

The purpose of this study is to test the safety and tolerability of a new drug called 2141-V11 in participants who have skin lesions associated with their cancer. It will also test how the body processes the drug and whether 2141-V11 has cancer fighting activity in humans.  The study drug …

  • 43 views
  • 23 Nov, 2020
  • 1 location
featured
SEVERE ASTHMA: WE'RE WORKING TO GIVE YOU MORE FREEDOM BETWEEN TREATMENTS

The NIMBLE Study is looking at a possible new medicine (study drug) for people with an eosinophilic asthma (a type of severe asthma).

  • 0 views
  • 22 Mar, 2021
  • 1 location
Use of Monoclonal Antibodies for the Treatment of Mild to Moderate COVID-19 in Non-Hospitalized Setting

No therapeutic agent is currently approved for the treatment of SARSCoV-2 infection. More importantly, no intervention is currently available to mitigate the progression of disease from mid/moderate to serve particularly in high risk patients. Recognizing this limitation and urgency of finding a treatment for COVID-19, the U.S. Food and Drug …

  • 0 views
  • 22 Apr, 2021
  • 3 locations
Combination Chemotherapy With or Without Filgrastim Before Surgery High-Dose Chemotherapy and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma

. Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Combining isotretinoin and monoclonal antibodies may kill

tumor cells
combination chemotherapy
monoclonal antibodies
monoclonal antibody ch14.18
high dose chemotherapy
  • 46 views
  • 07 Nov, 2020
  • 15 locations
Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil

. Cyclosporine may help irinotecan work better by making tumor cells more sensitive to the drug. Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the

tumor growth
panitumumab
tumor cells
fluorouracil
monoclonal antibodies
  • 129 views
  • 07 Nov, 2020
  • 12 locations