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Found 511 clinical trials
featured
  • 198 views
  • 23 Nov, 2020
  • 1 location
featured
  • 208 views
  • 13 Aug, 2020
  • 1 location
featured
A Phase 2a, Double-blind, Randomized, Placebo-controlled, Proof of Concept Study of Vascular Endothelial Growth Factor (VEGF)-B Blockade with the Monoclonal Antibody CSL346 in Subjects with Diabetic Kidney Disease.

We are currently recruiting participants for a clinical research study to evaluate the efficacy of an investigational medication in adults with Diabetic Kidney Disease.

kidney function tests
diabetic chronic kidney disease
diabetes
diabetic complications
hemoglobin a1c
  • 12 views
  • 14 Jan, 2021
  • 1 location
featured
A Phase 1/1b Study of Sitravatinib in Combination with Nivolumab and Ipilimumab in Patients with Advanced or Metastatic Clear-Cell Renal Cell Carcinoma or Other Solid Malignancies

related RTKs including the TAM family (Tyro3/Axl/MERTK), VEGFR2, KIT, and MET. NIVO/IPI are monoclonal antibodies (mAbs) that inhibit the immune checkpoint proteins programmed death receptor-1 (PD-1

VEGFR2
ipilimumab
carcinoma
systemic therapy
monoclonal antibodies
  • 27 views
  • 15 Sep, 2020
  • 1 location
featured
A 12-month, Randomized, Rater- and Dose-blinded Study to Compare the Efficacy and Safety of Fingolimod 0.25 mg and 0.5 mg Administered Orally Once Daily With Glatiramer Acetate 20 mg Administered Subcutaneously Once Daily in Patients With Relapsing-remitting Multiple Sclerosis

A 12-month, Randomized, Rater- and Dose-blinded Study to Compare the Efficacy and Safety of Fingolimod 0.25 mg and 0.5 mg Administered Orally Once Daily With Glatiramer Acetate 20 mg Administered Subcutaneously Once Daily in Patients With Relapsing-remitting Multiple Sclerosis

  • 74 views
  • 08 Nov, 2020
  • 1 location
featured
A Phase I, dose-escalation study investigating the safety and tolerability of intratumoral injection of an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) in patients with cancer

The purpose of this study is to test the safety and tolerability of a new drug called 2141-V11 in participants who have skin lesions associated with their cancer. It will also test how the body processes the drug and whether 2141-V11 has cancer fighting activity in humans.  The study drug …

  • 43 views
  • 23 Nov, 2020
  • 1 location
Combination Chemotherapy With or Without Filgrastim Before Surgery High-Dose Chemotherapy and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma

. Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Combining isotretinoin and monoclonal antibodies may kill

conventional surgery
bone marrow procedure
stem cell transplantation
cyclophosphamide
busulfan
  • 46 views
  • 07 Nov, 2020
  • 15 locations
Bevacizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help

adjuvant therapy
leucovorin
irinotecan
tumor growth
calcium
  • 7 views
  • 07 Nov, 2020
  • 1 location
Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil

. Cyclosporine may help irinotecan work better by making tumor cells more sensitive to the drug. Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the

panitumumab
fluorouracil
tumor cells
irinotecan
tumor growth
  • 129 views
  • 07 Nov, 2020
  • 12 locations
Combination Chemotherapy and Trastuzumab in Treating Women With Stage I Stage II or Stage III HER2-Positive Breast Cancer

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such

immunostimulant
adjuvant therapy
stage iii breast cancer
trastuzumab
HER2
  • 33 views
  • 07 Nov, 2020
  • 1 location