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Found 20 clinical trials
Ccf mtDNA as a Neurodegenerative Biomarker

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice. One of the most critical factors in biomarker research is the inadequate linkage of biological samples with data from …

stroke
multiple sclerosis
  • 3 views
  • 23 Jan, 2021
  • 1 location
Implementation of Molecular Diagnostic Pathways

For some neurological and neurodegenerative diseases genetic inheritance is well documented (described as Mendelian or multifactorial), but sometimes specific mutations or family segregation evidences have not been identified. Considering this scenario, most of the times it is impossible or unlikely to identify the responsible gene, or the private mutation, of …

  • 0 views
  • 22 Jan, 2021
  • 1 location
Diagnostic of Puumala Virus Infection in France

strains from Central or North Europe. Molecular diagnostic of these infection is not the rule. Consequently the objectives of the project are to evaluate the performances of the serological commercial

  • 0 views
  • 26 Jan, 2021
  • 15 locations
A Clinical Performance Study to Validate the Use of Novel Molecular Diagnostic Assays for the Detection of Cancer Biomarkers in Peripheral Blood and Primary Tumor Tissue Samples of Patients With Metastatic ER+/HER2- Breast Cancer

Conventional biopsy and surgical tumor resection are invasive procedures that capture only one instance of the progression of the tumor. However, the genome of tumor is not static, but it is constantly altered during treatment. Liquid biopsy is a non-invasive approach based on the extraction of information through peripheral blood …

erbb2
her2/neu-negative breast cancer
stage iv breast cancer
PIK3CA
HER2
  • 0 views
  • 24 Jan, 2021
  • 4 locations
A Clinical Performance Study to Validate the Use of Novel Molecular Diagnostic Assays for the Detection of Cancer Biomarkers in Peripheral Blood and Primary Tumor Tissue of Patients With Recurrent/Metastatic HNSCC Metastatic NSCLC or Metastatic Melanoma

Conventional biopsy and surgical tumor resection are invasive procedures that capture only one instance of the progression of the tumor. However, the genome of tumor is not static, but it is constantly altered during treatment. Liquid biopsy is a non-invasive approach based on the extraction of information through peripheral blood …

metastatic head and neck squamous cell carcinoma
nivolumab
liquid biopsy
lung cancer
cancer
  • 0 views
  • 25 Jan, 2021
  • 6 locations
Molecular Diagnosis of Idiopathic Interstitial Pneumonias: a Prospective Study

patients for a period of 3 years. The investigators will assess the impact of molecular diagnostic techniques on interobserver agreement during multi-disciplinary discussion. The

pneumonia
interstitial lung disease
ct scan
hypertension
pulmonary disease
  • 18 views
  • 25 Jan, 2021
  • 1 location
Monitoring Mutational Burden in Low Risk MDS Patients Using Sequential Peripheral Blood Samples

is currently the gold standard for most molecular diagnostic analyses. Not longer depending on the severe and for the patient painful collection of bone marrow aspirates we are now able to

erythropoietin
leukemia
bone marrow procedure
myeloid leukemia
cancer
  • 0 views
  • 23 Jan, 2021
  • 1 location
Ovarium Cancer Detection by TEP's and ctDNA

Rationale: Cancer is primarily diagnosed by clinical presentation, imaging and pathological analysis of tissue biopsies, increasingly supported by molecular diagnostics tests. However, late diagnosis and misdiagnosis due to limitations of tissue biopsy acquisition remains a major problem. Therefore, a general blood test to pinpoint cancer early and adequately can be …

cancer of the ovary
tumor cells
tumor markers
  • 15 views
  • 23 Jan, 2021
  • 3 locations
Next-Generation Sequencing Diagnostics of Bacteremia in Sepsis

Sepsis remains a major challenge, even in modern intensive care medicine. The identification of the causative pathogen is crucial for an early optimization of the antimicrobial treatment regime in patients with sepsis. In this context, culture-based diagnostic procedures (e.g. blood cultures) represent the standard of care, although they are associated …

sepsis
lactic acid
antibiotics
lactate level
systolic blood pressure
  • 7 views
  • 25 Jan, 2021
  • 23 locations
COVID-19 - Cytokine Storm

This is a multi-center study comparing clinical outcomes in patients with COVID-19 in subjects hospitalized at Hadassah and other hospitals for PCR or serology confirmed COVID-19 and compare the outcomes to the presence of different degrees of a cytokine storm. The patients will be subdivided into a mild, moderate, and …

SARS
covid-19
hypercytokinemia
cytokine storm
  • 0 views
  • 26 Jan, 2021
  • 1 location