molecular diagnostic Clinical Research Trials

Ccf mtDNA as a Neurodegenerative Biomarker

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice. One of the most critical factors in biomarker research is the inadequate linkage of biological samples with data from …

stroke

multiple sclerosis

3 views
23 Jan, 2021
1 location

Implementation of Molecular Diagnostic Pathways

For some neurological and neurodegenerative diseases genetic inheritance is well documented (described as Mendelian or multifactorial), but sometimes specific mutations or family segregation evidences have not been identified. Considering this scenario, most of the times it is impossible or unlikely to identify the responsible gene, or the private mutation, of …

0 views
22 Jan, 2021
1 location

Diagnostic of Puumala Virus Infection in France

strains from Central or North Europe. Molecular diagnostic of these infection is not the rule. Consequently the objectives of the project are to evaluate the performances of the serological commercial

0 views
26 Jan, 2021
15 locations

A Clinical Performance Study to Validate the Use of Novel Molecular Diagnostic Assays for the Detection of Cancer Biomarkers in Peripheral Blood and Primary Tumor Tissue Samples of Patients With Metastatic ER+/HER2- Breast Cancer

Conventional biopsy and surgical tumor resection are invasive procedures that capture only one instance of the progression of the tumor. However, the genome of tumor is not static, but it is constantly altered during treatment. Liquid biopsy is a non-invasive approach based on the extraction of information through peripheral blood …

erbb2

her2/neu-negative breast cancer

stage iv breast cancer

PIK3CA

HER2

0 views
24 Jan, 2021
4 locations

A Clinical Performance Study to Validate the Use of Novel Molecular Diagnostic Assays for the Detection of Cancer Biomarkers in Peripheral Blood and Primary Tumor Tissue of Patients With Recurrent/Metastatic HNSCC Metastatic NSCLC or Metastatic Melanoma

Conventional biopsy and surgical tumor resection are invasive procedures that capture only one instance of the progression of the tumor. However, the genome of tumor is not static, but it is constantly altered during treatment. Liquid biopsy is a non-invasive approach based on the extraction of information through peripheral blood …

metastatic head and neck squamous cell carcinoma

nivolumab

liquid biopsy

lung cancer

cancer

0 views
25 Jan, 2021
6 locations

Molecular Diagnosis of Idiopathic Interstitial Pneumonias: a Prospective Study

patients for a period of 3 years. The investigators will assess the impact of molecular diagnostic techniques on interobserver agreement during multi-disciplinary discussion. The

pneumonia

interstitial lung disease

ct scan

hypertension

pulmonary disease

18 views
25 Jan, 2021
1 location

Monitoring Mutational Burden in Low Risk MDS Patients Using Sequential Peripheral Blood Samples

is currently the gold standard for most molecular diagnostic analyses. Not longer depending on the severe and for the patient painful collection of bone marrow aspirates we are now able to

erythropoietin

leukemia

bone marrow procedure

myeloid leukemia

cancer

0 views
23 Jan, 2021
1 location

Ovarium Cancer Detection by TEP's and ctDNA

Rationale: Cancer is primarily diagnosed by clinical presentation, imaging and pathological analysis of tissue biopsies, increasingly supported by molecular diagnostics tests. However, late diagnosis and misdiagnosis due to limitations of tissue biopsy acquisition remains a major problem. Therefore, a general blood test to pinpoint cancer early and adequately can be …

cancer of the ovary

tumor cells

tumor markers

15 views
23 Jan, 2021
3 locations

Next-Generation Sequencing Diagnostics of Bacteremia in Sepsis

Sepsis remains a major challenge, even in modern intensive care medicine. The identification of the causative pathogen is crucial for an early optimization of the antimicrobial treatment regime in patients with sepsis. In this context, culture-based diagnostic procedures (e.g. blood cultures) represent the standard of care, although they are associated …

sepsis

lactic acid

antibiotics

lactate level

systolic blood pressure

7 views
25 Jan, 2021
23 locations

COVID-19 - Cytokine Storm

This is a multi-center study comparing clinical outcomes in patients with COVID-19 in subjects hospitalized at Hadassah and other hospitals for PCR or serology confirmed COVID-19 and compare the outcomes to the presence of different degrees of a cytokine storm. The patients will be subdivided into a mild, moderate, and …

SARS

covid-19

hypercytokinemia

cytokine storm

0 views
26 Jan, 2021
1 location

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Found 20 clinical trials