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Found 92 clinical trials
Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer

This phase I trial studies the side effects of pembrolizumab in treating patients with human immunodeficiency virus (HIV) and malignant neoplasms that have come back (relapsed), do not respond to treatment (refractory), or have distributed over a large area in the body (disseminated). Immunotherapy with monoclonal antibodies, such as pembrolizumab, …

b-cell lymphoma
lymphoma
antibody therapy
hcv viral load
liver transplant
  • 142 views
  • 28 Jul, 2022
  • 5 locations
Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

®; MK-3475)

neutrophil count
triple-negative breast cancer
HER2
breast cancer
invasive breast cancer
  • 0 views
  • 17 Mar, 2022
  • 5 locations
Efficacy and Safety Study of Anlotinib With Pembrolizumab in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Non-small Cell Lung Cancer

The purpose of this study is to assess the safety and efficacy of Anlotinib (AL3818) combined with pembrolizumab (MK-3475) in treatment-nave adults with no prior systemic therapy for advanced

proto-oncogene tyrosine-protein kinase ros
ROS1
solid tumour
cancer chemotherapy
secondary malignant neoplasm of liver
  • 0 views
  • 17 Feb, 2022
  • 1 location
Pre-op Pembro + Radiation Therapy in Breast Cancer (P-RAD)

positive/HER2-negative breast cancer. The names of the study interventions involved in this study are: Radiation Therapy (RT) Immunotherapy: Pembrolizumab (MK-3475)

HER2
paclitaxel
invasive breast cancer
mammogram
magnetic resonance imaging of breast
  • 0 views
  • 25 Mar, 2022
  • 6 locations
Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer

This trial studies the side effects of pembrolizumab with or without chemotherapy in treating patients with stage IV non-small cell lung cancer that has come back (recurrent) and has spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system …

  • 0 views
  • 06 May, 2022
  • 441 locations
Pembrolizumab (MK-3475) and Bacillus Calmette-Guérin (BCG) as First-Line Treatment for High-Risk T1 Non-Muscle-Invasive Bladder Cancer (NMIBC) and High-Grade Non-Muscle-Invasive Upper Tract Urothelial Carcinoma (NMI-UTUC)]

The purpose of this study is to find out the effectiveness of pembrolizumab in combination with BCG as a first line therapy for participants with high grade T1 bladder cancer who are at "high risk" for BCG alone to be ineffective and are seeking an alternative treatment option to radical …

neutrophil count
transurethral resection
radical cystectomy
bladder cancer
pembrolizumab
  • 19 views
  • 25 Jul, 2022
  • 7 locations
A Study of Belzutifan (MK-6482) as Monotherapy and in Combination With Lenvatinib (E7080/MK-7902) With or Without Pembrolizumab (MK-3475) in China Participants With Advanced Renal Cell Carcinoma (MK-6482-010)

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles, and preliminary efficacy of belzutifan as monotherapy followed by belzutifan+lenvatinib combination therapy, as well as belzutifan combined with lenvatinib and pembrolizumab in China participants with advanced renal cell carcinoma.

serum pregnancy test
pembrolizumab
clear cell renal cell carcinoma
carcinoma
systemic therapy
  • 0 views
  • 10 Aug, 2022
  • 5 locations
Safety and Immunological Effect of Pembrolizumab in Resectable or Borderline Resectable Pancreatic Cancer

The purpose of this clinical trial is to study an experimental drug called pembrolizumab or MK-3475 for use in combination with chemotherapy and radiation therapy for patients with resectable

solid tumour
resectable pancreatic cancer
cancer chemotherapy
pembrolizumab
chemoradiotherapy
  • 8 views
  • 21 Aug, 2021
  • 7 locations
Atezolizumab as Induction Therapy in Non-small Cell Lung Cancer (PRINCEPS)

pembrolizumab (MK-3475 or pembrolizumab) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy, and the second randomized phase III trial (NCT02273375

neutrophil count
ct scan
cancer chemotherapy
pembrolizumab
lung carcinoma
  • 0 views
  • 25 Feb, 2022
  • 1 location
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

This phase I trial studies the side effects and best dose of pembrolizumab and to see how well it works in treating younger patients with high-grade gliomas (brain tumors that are generally expected to be fast growing and aggressive), diffuse intrinsic pontine gliomas (brain stem tumors), brain tumors with a …

absolute neutrophil count
residual tumor
primary brain tumors
lymphoma
MRI
  • 111 views
  • 09 Aug, 2022
  • 6 locations