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Found 17 clinical trials
Neuroimmune Dysfunction in Alcohol Use Disorder

The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a

alcohol use disorder
heavy drinking
minocycline
Accepts healthy volunteers
  • 45 views
  • 10 Oct, 2021
  • 1 location
Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI

This is a Phase 3, multi-center, randomized, open-label, assess-blind study to determine the efficacy and safety of MLT, a novel antibiotic lock therapy that combines minocycline with edetate

minocycline
heparin
blood culture
antibiotics
antibiotic therapy
  • 69 views
  • 06 May, 2022
  • 19 locations
Discovery and Analytical Validation of Inflammatory Bio-signatures of the Human Pain Experience

activity in the brain via [11C]-carfentanil PET neuroimaging in healthy subjects. Another objective is to evaluate whether an anti-inflammatory drug that reduces activation of IL-1b (minocycline) will

opioid
Accepts healthy volunteers
  • 10 views
  • 24 Mar, 2022
  • 1 location
STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) (STAR-TER)

To evaluate the micro-biologic efficacy and safety of a streamlined treatment for early onset methicillin-resistant staphylococcus aureus (MRSA) in patients with cystic fibrosis.

nasal potential difference
sweat test
fibrosis
staphylococcus aureus
isoproterenol
  • 66 views
  • 02 Mar, 2022
  • 8 locations
PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

This phase II trial studies the effect of imipenem-relebactam in treating patients with cancer who have a fever due to low white blood cell counts (febrile neutropenia). In this study, imipenem-relebactam will be compared to the standard-of-care treatment (cefepime, meropenem, or piperacillin/tazobactam) for the treatment of febrile neutropenia. Imipenem-relebactam is …

neutropenia
cell transplantation
cancer
  • 0 views
  • 25 Jul, 2022
  • 1 location
The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans

There are currently no effective treatments for lichen planus pigmentosus (LPP) and erythema dyschromicum perstans (EDP). Tranexamic acid, which may downregulate pigmentation through a reduction in plasmin, has been shown to decrease pigmentation in patients with melasma, another pigmentary disorder. Given that LPP, EDP, and melasma are all disorders of …

  • 101 views
  • 13 Mar, 2022
  • 1 location
The Role of Gut Microbiota in Hypertension

hypothesize that gut microbiota is involved in the neuroinflammation-mediated initiation and establishment of RH, and targeting gut microbiota by minocycline would produce beneficial outcomes in RH.

hypertension
Accepts healthy volunteers
systolic blood pressure
cardiovascular disease
hypertensive medication
  • 80 views
  • 04 Jun, 2022
  • 1 location