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Found 18 clinical trials
Minocycline as Adjunctive Treatment for Treatment Resistant Depression (MINDEP2)

some patients with MDD including those with TRD, display brain inflammation. Thus, patients with TRD may benefit from medications that can reduce this inflammation. Minocycline is an antibiotic which

duloxetine
mirtazapine
depressive episode
venlafaxine
adjunctive treatment
  • 108 views
  • 12 May, 2022
  • 1 location
Neuroinflammation in Hypertension Study

To demonstrate that in patients with resistant hypertension oral treatment with minocycline via inhibition of central immune cell activation and inflammation results in reduced central

  • 1 views
  • 05 Oct, 2021
  • 1 location
Enhanced Bioscaffold for Volumetric Muscle Loss (MTEC VML)

This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix™ AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.

  • 0 views
  • 27 Feb, 2022
  • 1 location
Minocycline Treatment in Retinitis Pigmentosa

The aim of this study is to evaluate the efficacy and safety of oral minocycline (100mg/d), administered for 6 months, for the treatment of patients with retinitis pigments(RP).

electroretinogram
retinitis
blindness
flashes
minocycline
  • 269 views
  • 28 Feb, 2022
  • 1 location
Minocycline in MS: Confirmation of Benefit (MS)

with minocycline until the endpoint is reached or to a maximum of 24 months or until the last-enrolled participant reaches their 12 month visit.

demyelination
demyelinating disorder
oligoclonal bands
disease or disorder
MRI
  • 11 views
  • 28 Feb, 2022
  • 1 location
Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia

This a randomized double-blind placebo controlled trial which aims to determine the beneficial effects of minocycline augmentation to clozapine in partial responders to Treatment Resistant

clozapine
schizophrenia
antipsychotics
  • 43 views
  • 09 May, 2022
  • 4 locations
Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline

site will be challenged with up to three known allergens, saline and histamine controls. Mean wheal diameter after 20 minutes challenge will be determined. This is followed by placement of minocycline

  • 0 views
  • 20 Oct, 2021
  • 1 location
To Evaluate the Efficacy and Safety of Minocycline Hydrochloride Foam in the Treatment of Moderate-to-severe Acne Vulgaris

This is a randomized, multicenter, double-blind, vehicle-controlled, 2-arm study to evaluate the safety and efficacy in 12 weeks of FMX101 minocycline foam, 4%, compared to vehicle, in the

  • 0 views
  • 29 Dec, 2021
  • 20 locations
Evaluating the Role of Neuroinflammation in Low Back Pain

In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain. The efficacy of minocycline

acute back pain
brain imaging
low back pain
back pain
  • 370 views
  • 22 Sep, 2021
  • 1 location
Neuroprotection in Acute Ischemic Stroke (H2M)

This is a pilot randomized control trial (RCT) to explore the possible beneficial effect of a novel combination therapy consisting of molecular hydrogen H2 plus minocycline ("H2M"), on

stroke
  • 21 views
  • 12 Mar, 2022
  • 1 location