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Found 16 clinical trials
Minocycline as Adjunctive Treatment for Treatment Resistant Depression (MINDEP2)

some patients with MDD including those with TRD, display brain inflammation. Thus, patients with TRD may benefit from medications that can reduce this inflammation. Minocycline is an antibiotic which

adjunctive treatment
bupropion
duloxetine
venlafaxine
depressive episode
  • 110 views
  • 07 Oct, 2022
  • 1 location
Influence of Scaling and Root Planing With Minocycline Microspheres on the Composition and Functional Characteristics of Subgingival Microbiome Communities

The purpose of this study is to characterize the effect of minocycline microspheres (MM) administered as an adjunct to scaling and rooting planning (SRP) on the subgingival community composition

Accepts healthy volunteers
root planing
minocycline
dental plaque
debridement
  • 1 views
  • 24 Oct, 2022
  • 1 location
The Role of Neuroinflammation in Hypertension.Minocycline for Resistant Hypertension: a Randomized Double Blind Placebo-Controlled Trial (MINIHT)

To demonstrate that in patients with resistant hypertension oral treatment with minocycline via inhibition of central immune cell activation and inflammation results in reduced central

  • 1 views
  • 15 Oct, 2022
  • 1 location
Enhanced Bioscaffold for Volumetric Muscle Loss (MTEC VML)

This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix™ AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.

  • 0 views
  • 27 Feb, 2022
  • 1 location
Minocycline Treatment in Retinitis Pigmentosa

The aim of this study is to evaluate the efficacy and safety of oral minocycline (100mg/d), administered for 6 months, for the treatment of patients with retinitis pigments(RP).

retinitis
electroretinogram
flashes
minocycline
blindness
  • 269 views
  • 28 Feb, 2022
  • 1 location
Minocycline in MS: Confirmation of Benefit (MS)

with minocycline until the endpoint is reached or to a maximum of 24 months or until the last-enrolled participant reaches their 12 month visit.

disease or disorder
brain mri
demyelination
demyelinating disorder
MRI
  • 11 views
  • 28 Feb, 2022
  • 1 location
Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia

This a randomized double-blind placebo controlled trial which aims to determine the beneficial effects of minocycline augmentation to clozapine in partial responders to Treatment Resistant

antipsychotics
clozapine
schizophrenia
  • 43 views
  • 09 May, 2022
  • 4 locations
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients

perhaps eventually cure neurogenic hypertension (NH). This study is designed to evaluate a low and high dose of minocycline to test the hypothesis that minocycline treatment would produce antihypertensive

cardiovascular disease
diuretics
metabolic syndrome
diabetes
systolic blood pressure
  • 41 views
  • 08 Jun, 2022
  • 1 location
Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline

site will be challenged with up to three known allergens, saline and histamine controls. Mean wheal diameter after 20 minutes challenge will be determined. This is followed by placement of minocycline

  • 0 views
  • 20 Oct, 2021
  • 1 location
Characterization of Neuroimmune Dysfunction in Alcohol Use Disorder

The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a

Accepts healthy volunteers
heavy drinking
minocycline
alcohol use disorder
  • 45 views
  • 27 Oct, 2022
  • 1 location