Found 70 clinical trials
Acute Exposure of Individuals With Down Syndrome to Gamma Frequency Stimulation
Down Syndrome (DS) is characterized by an additional copy of chromosome 21, which also increases risk of Alzheimer's Disease (AD). The investigators' lab found a non-invasive way to remove toxic proteins from the brain in AD mouse models. Remarkably, treated mice also have improved memory on behavioral testing. The investigators …
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- 23 Oct, 2022
- 1 location
Effects of Intermittent Fasting on Insulin Resistance, Cardiac Metabolism, and Cerebral Perfusion
The overall purpose of the study is to investigate whether three weeks of intermittent fasting (alternate-day fasting, (ADF)) result in a more pronounced "metabolic shift" towards the use of ketone bodies than three weeks of Western diet. The investigators will use state-of-the-art PET/CT tracer techniques and well-established steady state kinetics …
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- 27 May, 2022
- 1 location
PUMCH Dementia Longitudinal Cohort Study
The PUMCH Dementia Cohort is a hospital-based, observational study of Chinese elderly with cognitive impairment.
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- 07 Oct, 2022
- 1 location
Diagnosis and Monitoring of Disease Progression Using Deep Neuro Signatures (DNS)
Alzheimer's disease (AD) clinically characterized by the cognitive impairment and lowering of various functional abilities lead to staggering costs and suffering, which are particularly related to the social impacts of caring for increasingly disabled individuals. Some of these changes can be almost undetectable in the early stages of the disease, …
- 0 views
- 22 Mar, 2022
Amyloid-β Clearance Mechanisms in Alzheimer's Disease (AmyClearAD)
to achieve this aim the investigators intend to study participants with a Subjective Cognitive Decline, Mild Cognitive Impairment and a mild Alzheimer's disease.
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- 25 Jan, 2022
Optina Diagnostics' Cerebral ß-Amyloid Status (CAS) Test (REPHRASE)
This observational, cross-sectional study is designed to validate a novel diagnostic test for the detection of phenotypic changes in the retina that correlate with likely PET amyloid status (negative or positive), to aid in the evaluation of adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and …
- 0 views
- 11 Apr, 2023
- 1 location
Event-Related Potential (ERP) Components in Clinical Diagnosis
In this study, the investigators will use a novel electroencephalogram (EEG) system that participants will wear during a single in-person research session to investigate whether ERPs are now ready for validation as a tool clinicians can easily implement to increase diagnostic accuracy and confidence. This EEG will not be used …
- 0 views
- 09 Apr, 2023
- 1 location
Atlas of Retinal Imaging in Alzheimer's Study (ARIAS)
The Atlas of Retinal Imaging in Alzheimer's (ARIAS) study is a 5-year study examining the natural history of retinal imaging biomarkers associated with disease risk, disease burden, and disease progression in Alzheimer's disease (AD). The objective of this project is to create a 'gold standard' reference database of structural anatomic …
- 0 views
- 25 Jan, 2022
- 3 locations
Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
MCI and mild dementia due to AD. The present study has two main objectives that are: To characterize from a cognitive and biomarker (when available) point of view persons with
- 32 views
- 03 Apr, 2023
- 1 location
An Observational Longitudinal Cohort Study to Investigate Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease (CONGA)
The aim of this study is to find out whether a new image analysis technique called Cortical Disarray Measurement (CDM) could be used to help better diagnose Alzheimer's disease. This study will see whether changes on CDM can be used to identify Alzheimer's disease from a group of people living …
- 0 views
- 23 Oct, 2022
- 1 location