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Found 70 clinical trials
The PREVENTION Trial: Precision Recommendations to Optimize Neurocognition (PREVENTION)

based on three categories: 1) a diagnosis of mild AD according to criteria established by the National Institute of Neurological and Communicative Disorders and Stroke (AD and Related Disorders

cognitive decline
neurodegenerative disorders
amyloid
stroke
positron emission tomography
  • 20 views
  • 28 Jun, 2022
  • 1 location
A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011) (Hope)

This is a randomized, double-blind, sham-controlled, adaptive-design pivotal study of sensory stimulation in subjects with mild to moderate Alzheimer's disease. Approximately 345 subjects will be randomized to 12 months of daily treatment with either Active or Sham Sensory Stimulation Systems. Efficacy will be measured using the Alzheimer's Disease Cooperative Study- …

mental state examination
amyloid
alzheimer's disease
cognitive assessment
mini-mental state examination
  • 5 views
  • 08 Apr, 2023
  • 5 locations
ASURE: Alzheimer Study Using oRal Edaravone

This is a multi-center, Phase IIa, randomized, double-blind, placebo-controlled study in patients with Alzheimer's Disease (AD).

  • 0 views
  • 07 Apr, 2023
  • 2 locations
SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD): A Multi-center, Randomized, Double-Blind, Placebo-Controlled Safety and Biomarker Study of Pepinemab Anti-SEMA4D Antibody in Early-AD (SIGNAL-AD)

To investigate safety, tolerability, the effects on cognition and brain metabolism of pepinemab in early AD dementia (early AD) subjects.

galantamine
cognitive impairment
dementia
rivastigmine
florbetapir
  • 103 views
  • 25 Oct, 2022
  • 14 locations
Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

This study compares different music therapy (MT) experiences and their impact on memory and language in patients with Alzheimer's disease and Mild Cognitive Impairment. The 12-month study will assess the role of common experiences involving familiar music and other pleasant events (blinded control) to benefit cognition and measure the quality …

alzheimer's disease
cognitive assessment
cognitive impairment
mild cognitive impairment
  • 2 views
  • 25 Jan, 2022
  • 2 locations
Perturbation Training for Reducing Falls in People With Alzheimer's Disease

This study will examine the overall capacity of people with Alzheimer's disease learning fall-resistant skills from perturbation training.

alzheimer's disease
mini-mental state examination
  • 0 views
  • 28 Oct, 2022
  • 1 location
Sirtuin-NAD Activator in Alzheimer's Disease

The primary objectives are to: To determine whether MIB-626, after its daily oral administration, penetrates the blood-brain barrier in humans by measuring the cerebrospinal fluid (CSF) concentrations of MIB-626 and its key metabolites, nicotinamide (NAM), NR, 2-PY, and MeNAM at baseline and on day 90 at steady state. To evaluate …

cholinesterase inhibitors
cholinesterase
dementia
cognitive assessment
mini-mental state examination
  • 0 views
  • 04 Oct, 2022
  • 1 location
Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease

Alzheimer's disease (AD) is the leading neurodegenerative disease of aging characterized by multiple cognitive impairments. Given the recent failures of disease-modifying drugs, the current focus is on preventing or mitigating synaptic damage that correlates with cognitive decline in AD patients. Transcranial Direct Current Stimulation (tDCS) is a safe, non-invasive, non-painful …

cognitive decline
neurodegenerative disorders
cognitive impairment
Accepts healthy volunteers
amyloidosis
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD (VIVA-MIND)

This is a phase 2A multi-center, randomized, double blind, placebo-controlled, parallel group study of varoglutamstat, with a stage gate to phase 2B. In phase 2A there will be adaptive dosing evaluation of three dose levels with exposure to varoglutamstat or placebo for a minimum of 24 weeks, with preliminary evaluation …

mental state examination
cognitive impairment
mild cognitive impairment
dementia
alzheimer's disease
  • 0 views
  • 07 Apr, 2023
  • 18 locations
High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease

Parkinson's disease (PD) impacts different types of neural oscillations in the brain, including beta (13-30Hz) and gamma oscillations (30-80Hz), which contributes to PD's cardinal symptoms of resting tremor, rigidity, bradykinesia (slowness of movement), and gait instability. The investigators' lab has developed a non-invasive method of increasing gamma power in the …

  • 0 views
  • 07 Apr, 2023
  • 1 location