Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 61 clinical trials
Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

This randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of gantenerumab versus placebo in participants with early (prodromal to mild) AD

cognitive impairment
mild cognitive impairment
dementia
mini-mental state examination
cognitive assessment
  • 1959 views
  • 13 Feb, 2021
  • 1 location
Effectiveness of Alzheimer's Universe (Www.AlzU.Org) on Knowledge and Behavior

To evaluate the effectiveness of an online educational course on Alzheimer's disease (AD) prevention, treatment and caregiving.

alzheimer's disease
cognitive impairment
mild cognitive impairment
cognitive decline
amnesia
  • 190 views
  • 24 Jan, 2021
  • 1 location
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU001

The purpose of this study is to assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer's disease-causing mutation by determining if treatment with the study drug slows the rate of progression of cognitive impairment and improves disease-related biomarkers.

mild dementia
cognitive impairment
mild cognitive impairment
dementia
positron emission tomography
  • 980 views
  • 25 Jan, 2021
  • 57 locations
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and …

cognitive impairment
mild cognitive impairment
dementia
hmg-coa reductase inhibitor
primary prevention
  • 104 views
  • 26 Jan, 2021
  • 87 locations
Two-Phased Study of SPIRIT in Mild Dementia

The proposed study will adapt and pilot test an efficacious advance care planning interventions, SPIRIT (Sharing Patient's Illness Representations to Increase Trust), with patients with mild

mild dementia
dementia
moderate dementia
mini-mental state examination
cognitive assessment
  • 10 views
  • 25 Jan, 2021
  • 5 locations
NMDA Enhancer for the Treatment of Mild Alzheimer's Disease

NMDA neurotransmission plays an important role in learning and memory. NMDA receptors (NMDAR) were found to decrease in the frontal lobe and hippocampus of Alzheimer's disease (AD). This study is a randomized, double-blind, placebo controlled drug trial for testing the efficacy of NMDAR-enhancer. All subjects will be allocated randomly to …

mini-mental state examination
  • 5 views
  • 02 Feb, 2021
  • 1 location
Clinical Trial to Determine Tolerable Dosis of Vorinostat in Patients With Mild Alzheimer Disease

This Clinical Trial is an open, non-randomized Phase Ib study to determine the maximal tolerable dose (MTD) of Vorinostat in Alzheimer disease (AD) patients between (including) 55 and 90 years with mild symptoms. The MTD in this study is defined as the dose that leads to maximum toxicity with Common …

mini-mental state examination
mental state examination
  • 25 views
  • 23 Jan, 2021
  • 4 locations
Deep Brain Stimulation With LIFUP for Mild Cognitive Impairment and Mild Alzheimer's Disease

activity of neurons in a certain part of the brain or decrease the activity of neurons. The investigators will study up to 8 subjects with MCI or mild AD. Initially, subjects will undergo a

cognitive impairment
mild cognitive impairment
dementia
cognitive assessment
cholinesterase inhibitors
  • 6 views
  • 27 Jan, 2021
  • 2 locations
ADvance II Study: DBS-f in Patients With Mild Alzheimer's Disease

The primary efficacy objective of this study is to test the hypothesis that DBS-f stimulation (ON) will slow cognitive and functional progression of AD, as compared to no stimulation (OFF), by measuring baseline (pre-implantation) to 12-month change in the integrated Alzheimer's disease rating scale (iADRS).

dementia
cholinesterase inhibitors
rivastigmine
mild dementia
donepezil
  • 117 views
  • 29 Jan, 2021
  • 33 locations
4Hz Transcranial Alternating Current Stimulation for Patients With Mild Alzheimer's Disease

The goal of this study is to explore the efficacy and safety of 4Hz transcranial alternating current stimulation (tACS) in patients with mild Alzheimer's disease (AD). The study will recruit 40

dementia
amyloid
cholinesterase inhibitors
rivastigmine
donepezil
  • 0 views
  • 23 Jan, 2021
  • 1 location