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Found 20 clinical trials
Evaluation of 2 Intensification Treatment Strategies for Neuroblastoma Patients With a Poor Response to Induction (VERITAS)

The main objective is to evaluate the efficacy of two intensified consolidation strategies in very-high risk neuroblastoma (VHR-NBL) patients in terms of event-free survival from randomisation date. This evaluation will follow a hierarchical testing procedure: each experimental treatment will be first evaluated as a single-arm phase 2 study, and in …

  • 5 views
  • 27 Feb, 2022
  • 2 locations
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

This phase III trial studies iobenguane I-131 or lorlatinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Lorlatinib may stop the growth of tumor cells by blocking …

topotecan
thiotepa
conventional surgery
shortening fraction
busulfan
  • 117 views
  • 25 Jul, 2022
  • 102 locations
Diagnosis of Pheochromocytoma

carried out. Standard imaging tests - Non-investigational imaging tests include computed tomography (CT), magnetic resonance imaging (MRI), sonography, and 123I-MIBG scintigraphy and FDG

positron emission tomography/computed tomography
clonidine
blood test
computed tomography
18f-fdg
  • 20 views
  • 28 Jul, 2022
  • 1 location
MIBG With Dinutuximab +/- Vorinostat

131I-Metaiodobenzylguanidine (131I-MIBG) is one of the most effective therapies utilized for neuroblastoma patients with refractory or relapsed disease. In this pediatric phase 1 trial, 131I

iobenguane
monoclonal antibodies
monoclonal antibody ch14.18
cancer
vorinostat
  • 38 views
  • 25 May, 2022
  • 11 locations
MIBG for Refractory Neuroblastoma and Pheochromocytoma

This is a best available therapy/compassionate use single institution study designed to determine the palliative benefit and toxicity of 131I-MIBG in patients with progressive neuroblastoma and

g-csf
iobenguane
biologics
stem cell infusion
total body irradiation
  • 5 views
  • 23 Mar, 2022
  • 1 location
18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma

called 123I-mIBG. However, the picture it provides is not always clear enough to see the very small areas of the disease. 18F-DA (18F-fluorodopamine) has been shown to be safe and more effective

positron emission tomography
iobenguane
adrenal pheochromocytoma
positron emission tomography/computed tomography
pheochromocytoma
  • 8 views
  • 24 Mar, 2022
  • 1 location
A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects (OPTIMUM)

The purpose of this study is to evaluate the efficacy and safety of 131I-MIBG in combination with Vorinostat in patients with Recurrent or Progressive neuroblastoma

ifosfamide
total bilirubin
topotecan
shortening fraction
platelet count
  • 58 views
  • 24 Mar, 2022
  • 16 locations
Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma

The purpose of this research study is to find how active and safe 131 I-MIBG is in patients with resistant neuroblastoma, malignant pheochromocytoma and malignant paraganglioma.

biological therapy
iobenguane
adrenal pheochromocytoma
iodine i 131 metaiodobenzylguanidine
stem cell transplantation
  • 39 views
  • 25 Jul, 2022
  • 1 location
68Ga-DOTATATE Neuroblastoma Imaging Pilot

and safety of 68Ga-DOTATATE and to compare it to 123I-MIBG when investigating neuroblastoma.

68ga-dotatoc
  • 0 views
  • 05 Jun, 2022
  • 2 locations
An Investigational Scan (68Ga-DOTATATE PET/CT) in Diagnosing Pediatric Metastatic Neuroendocrine Tumors

radiotracer that when used with PET/CT scans, may work better than standard of care MIBG scans in diagnosing pediatric metastatic neuroendocrine tumors and targeting them with radiation therapy.

68ga-dotatoc
ganglioneuroblastoma
  • 0 views
  • 27 Jun, 2021
  • 1 location