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Found 56 clinical trials
Bezlotoxumab Yielded Outcomes by Addressing Personalized Needs in Clostridioides Difficile Infection (BEYOND)

Previous data have shown that integrated information from single nucleotide polymorphisms (SNPs) of the host DNA, interleukin 8 (IL-8) and the enrichment of the stool microbiome can indicate the patients with infection by Clostridioides difficile (CDI) who are at risk for unfavorable outcome. This integrated information is forming the BEYOND …

  • 26 May, 2022
  • 7 locations
Reducing the Incidence of Incisional Hernia After Stoma Closure Using a Prophylactic Mesh

Background Preliminary studies have shown that application of a prophylactic mesh during stoma closure reduces the incidence of incisional hernia at site of stoma closure. Methods/Design: The study will be a randomized controlled single-blinded monocentric study determining the 1-year incidence of incisional hernia in cancer patients undergoing ileostomy or colostomy …

  • 26 Apr, 2021
  • 1 location
"Surgical vs. Non-surgical Peri-implant Therapy"

The aim of this randomized clinical trial is to evaluate the effectiveness, in terms of clinical and radiographic changes, of non-surgical peri-implant therapy (mechanical/chemical) versus regenerative surgical therapy (xenograft and collagen membrane), after a follow-up period of 12 months.

Accepts healthy volunteers
  • 12 Mar, 2022
  • 1 location
European Registry on the Management of Helicobacter Pylori Infection

The great diversity of regimens and treatment lines, the different efficacy of these, mostly due to the increase in bacterial antibiotic resistance and regional differences, requires a continuous critical analysis of clinical practice, evaluating systematically the efficacy and safety of the different regimens and the cost-effectiveness of the different diagnostic-therapeutic …

peptic ulcer
antibiotic therapy
gastric cancer
  • 07 Sep, 2021
  • 30 locations
Perioperative Tissue Penetration of Antimicrobials in Infants

This study aims to define the pharmacokinetic (PK) properties of a commonly used antibiotic to treat cIAI, metronidazole, in the intestinal wall tissue of healthy infants undergoing intestinal

  • 21 Mar, 2022
  • 1 location
Microbiota Implementation to Reduce Anastomotic Colorectal Leaks (MIRACLe)

Aim of this study is to implement the intestinal microbiota by perioperative administration of probiotics, oral antibiotics and low volume mechanical preparation in order to reduce the incidence of colorectal anastomotic leaks and dehiscences.

Accepts healthy volunteers
  • 01 Jan, 2022
  • 1 location