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Found 75 clinical trials
Specific Methylation Profiles in HNSCC

In the study, N-20190047, the investigators aim to define specific methylation patterns in a group of patients with head and neck squamous cell carcinomas. With this study the investigators aim to validate these findings in a larger cohort.

Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 1 location
Mitochondrial Methylation in Type 2 Diabetes

The overarching goal of this proposal is to determine whether DNA methylation of the mitochondrial DNA impairs mitochondrial function in insulin resistant states such as overweight/obesity and type 2 diabetes.

Accepts healthy volunteers
body mass index
insulin
hemoglobin a1c
diabetes
  • 8 views
  • 23 Mar, 2022
  • 1 location
Vitamin C Supplementation to Pregnant Smokers: Follow-up of 2 Randomized Trials Plus Changes in DNA Methylation (VCSIP-ECHO)

In a randomized clinical trial (RCT) published in JAMA, the investigators have provided evidence that vitamin C supplementation (500 mg daily during pregnancy) ameliorates the effects of maternal smoking during pregnancy on offspring lung function and subsequent incidence of wheeze by 48% through 1 year of age. The investigators are …

asthma
wheezing
vitamin c supplementation
pulmonary function test
  • 40 views
  • 24 May, 2022
  • 2 locations
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN)

Despite advancements in medical care, ischemic heart disease (IHD) remains the leading global cause of death. IHD develops through lipid accumulation into the coronary arteries with subsequent formation of larger atherogenic plaques. During myocardial infarction (MI), a plaque ruptures and subsequent occlusion leads to a death of the heart muscle. …

  • 0 views
  • 26 Jan, 2021
  • 1 location
The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism

The Metabolism, Infection and Immunity (MINI) Study is a longitudinal natural history study at the National Institutes of Health (NIH) that aims to define the relationship between infection, immunity and clinical decline in individuals with mitochondrial disease. Mitochondrial diseases are a group of disorders caused by problems with the cell …

Accepts healthy volunteers
lab testing
influenza
vaccination
  • 39 views
  • 16 Jun, 2022
  • 1 location