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Found 75 clinical trials
Host DNA Methylation for Endometrial Cancer Screening

Based on the previous study of NCT04651738, we performed this trial to further confirm the accuracy of host DNA CDO1 and CELF4 methylation for endometrial cancer screening in a multi-center cohort. Thirteen hospitals, including Peking Union Medical College Hospital, would enroll eligible patients in this study. The cervical cytology of …

hysterectomy
cancer
  • 0 views
  • 09 Apr, 2022
  • 1 location
A Community Population Screening Cohort Study Based on Polygene Methylation Detection for Colorectal Cancer in Yangzhou

This is a cross-sectional cohort study based on community population jointly developed by Northern Jiangsu People's Hospital and Shanghai Kunyuan Biological Technology Co., LTD. This study will verify the real world results of polygene methylation detection of colorectal cancer in a large prospective cohort of community population, which is expected …

Accepts healthy volunteers
  • 0 views
  • 16 May, 2022
  • 2 locations
Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules

This trial studies how well the diagnostic deoxyribonucleic acid (DNA) methylation signature works in detecting thyroid cancer in patients with thyroid nodules. Using diagnostic testing, such as the diagnostic DNA methylation signature, may be a less invasive way to check for thyroid cancer.

fine needle aspiration
aspiration
cancer
  • 51 views
  • 29 May, 2022
  • 1 location
PENK Methylation Test for Detecting Bladder Cancer

The primary objective of this clinical trial is to determine the sensitivity and specificity of the EarlyTect® Bladder Cancer test for bladder cancer among patients with hematuria by comparing it to the results of cystoscopy examinations. The second objective is to compare the clinical performance of EarlyTect® Bladder Cancer test …

urine cytology
cystoscopy
hematuria
bladder tumor
  • 0 views
  • 24 Mar, 2022
  • 1 location
A Stool DNA-based SDC2 Methylation Test for the Early Detection of Colorectal Cancer

The primary objective of this clinical trial is to determine the sensitivity and specificity of the EarlyTect® CRC test for detecting CRC, using colonoscopy as the reference method. The secondary objective is to compare the clinical performance of EarlyTect® CRC test with a commercially available Fecal Immunochemical Test (FIT), with …

  • 0 views
  • 08 Mar, 2022
  • 1 location
Ccf mtDNA as a Neurodegenerative Biomarker

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice. One of the most critical factors in biomarker research is the inadequate linkage of biological samples with data from …

multiple sclerosis
Accepts healthy volunteers
stroke
cancer
  • 3 views
  • 16 May, 2022
  • 1 location
Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight

Simons Searchlight collects medical, behavioral, learning, and developmental information from people who have gene changes that are linked to autism and other neurodevelopmental disorders. The goal of this study is to improve the clinical care and treatment for these people. Simons Searchlight partners with families to collect data and distribute …

simons
genetic testing
  • 577 views
  • 03 Oct, 2021
  • 3 locations
Fecal DNA Methylation Test for Colorectal Cancer Screening

fecal specimens from participants will be examined by FIT and multi-methylated target gene detection through real-time quantitative methylation-specific PCR (qMSP). The objective of this study

  • 0 views
  • 15 Apr, 2021
  • 1 location
Relapse Markers for Colorectal Cancer

test for the detection of relapse in colorectal cancer patients. This test is based on whole-blood transcriptomic signatures and circulating tumor methylated DNA markers. The patients will be enrolled

  • 0 views
  • 20 Jun, 2021
  • 1 location
Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain (LEAP)

Genetic variability from epigenetic modification of genes related to pain physiology and opioid pharmacodynamics may influence susceptibility to high-impact chronic musculoskeletal pain, opioid efficacy, and vulnerability to opioid abuse. Exploring the role of epigenomics and opioid addiction may improve understanding and treatment of these complex multifactorial conditions and, potentially, reduce …

drug abuse
analgesics
Accepts healthy volunteers
addiction
opioid
  • 242 views
  • 28 Jun, 2022
  • 2 locations