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Found 76 clinical trials
Genetic Aspects of Vaginal Aging

epigenetic modification plays an important role in a variety of cellular processes, such as differentiation, transformation and aging. The most commonly methylated are cytosines within two nucleotide

Accepts healthy volunteers
  • 0 views
  • 23 Apr, 2022
Detection of Plasma DNA Methylation in Peripheral Blood From Patients With Resectable Liver Cancer

This study explores the potential values of a new blood test approach to detect measurable residual disease or early coming back of cancer (recurrence)/cancer growing, spreading, or getting worse (progression) in patients with liver cancer that can be removed by surgery (resectable). The development of novel cancer biomarkers for liver …

  • 0 views
  • 22 Mar, 2022
  • 1 location
Fetal Exposure to Cannabinoids: Exposure, Methylation and Neurodevelopmental Effects

Cannabis is a very popular drug for both recreational and medicinal use. An estimated 20% of adults in the United States report using cannabis in the past month, and this number continues to increase each year. As of 2018, medical use of cannabis is legal in 33 states and the …

Accepts healthy volunteers
  • 0 views
  • 16 May, 2022
  • 1 location
Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer and Cervical Cancer

The overarching objective of this project is to develop a uterine (endometrial and cervical) cancer detection test using unique endometrial cancer-specific methylated DNA markers and high-risk

human papilloma virus vaccine
hpv vaccine
cancer
diagnostic procedures
papilloma
  • 0 views
  • 21 Oct, 2021
  • 1 location
Development of Free DNA Multi-target Methylated PCR for Auxiliary Diagnosis of Gastric Cancer

This was a case control, non-intervention study jointly developed by Fudan University Cancer Hospital and Shanghai Singlera Genomics Company. The enrolled population was screened by gastric surgery, including gastric cancer, precancerous lesions, benign lesions, and healthy control group. 10ml of whole blood of the enrolled subjects was collected for multi-target …

Accepts healthy volunteers
  • 0 views
  • 05 May, 2022
  • 1 location
Developing Novel Circulating Epigenetic Biomarkers for Early Detection of Lung Cancer

The investigators aim to identify novel circulating methylated biomarkers for early lung cancer detection as well as to develop new technologies that are clinically applicable with high

Accepts healthy volunteers
  • 0 views
  • 25 May, 2022
  • 1 location
Non-invasive Risk Stratification of CR AMN/SSP (FIT)

The purpose of this study is to determine the clinical utility of stool and blood methylation tests for detection of advanced mucosal neoplasia (AMN) and sessile serrated polyps (SSP).

Accepts healthy volunteers
  • 0 views
  • 01 Mar, 2022
  • 1 location
cfMeDIP-seq Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease (CAMPERR)

This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, …

cancer treatment
lymphoma
Accepts healthy volunteers
sarcoma
multiple myeloma
  • 0 views
  • 04 Jun, 2022
  • 2 locations
DNA CDO1 and CELF4 Methylation for Endometrial Cancer Screening

Based on the previous study of NCT04651738, we performed this trial to further confirm the accuracy of host DNA CDO1 and CELF4 methylation for endometrial cancer screening. This study would provide profound basis for the approval of assay kit of DNA methylation in China for endometrial screening. Four hospitals, including …

hysterectomy
cancer
  • 0 views
  • 07 Apr, 2022
  • 1 location
Genetic and Epigenetic Risk of T2D in the UAE

T2D is a global public health crisis and a threat to socioeconomic development of all nations, particularly in developing countries. Countries in the Gulf region, including the UAE, have some of the highest rates of T2D worldwide. The epidemic in the region has grown in parallel with the worldwide rise …

glucose intolerance
type 2 diabetes mellitus
Accepts healthy volunteers
diabetes
  • 38 views
  • 27 Feb, 2022
  • 1 location