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Found 75 clinical trials
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma

uMGMT Arm B: evaluating the combination of selinexor with radiation therapy and temozolomide (TMZ) (S-TRT) in nGBM participants with methylated-O6-methylguanine-DNA-methyltransferase (mMGMT

carmustine
measurable disease
brain tumor
methylated
recurrent glioblastoma
  • 40 views
  • 24 Apr, 2022
  • 17 locations
Prevention of Gestational Diabetes (NuPreGDM)

early in the first trimester. Comparative analyses of DNA methylation patterns in the offspring of women with or without GDM revealed preferentially methylated genes, particularly in pathways linked to

dietary modification
Accepts healthy volunteers
sugars
flash
nutrition education
  • 3 views
  • 14 Apr, 2022
  • 1 location
Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced, MSS, Locally Advanced RecTal Cancer (CATARTIC)

-methylated pretreated metastatic colorectal cancer and responses are restricted to tumors with complete MGMT loss by immunohistochemistry (IHC) and microsatellite stable (MSS) status. Both

fluorouracil
chemoradiotherapy
capecitabine
oxaliplatin
adenocarcinoma
  • 0 views
  • 24 Mar, 2022
  • 1 location
Nivolumab BMS-986205 and Radiation Therapy With or Without Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

This phase I trial studies the side effects of nivolumab, BMS-986205, and standard radiation therapy with or without temozolomide in treating patients with new diagnosed glioblastoma. Immunotherapy with nivolumab, may induce changes in body?s immune system and may interfere with the ability of tumor cells to grow and spread. BMS-986205 …

neutrophil count
tumor cells
tumour resection
temozolomide
blood transfusion
  • 0 views
  • 24 Jan, 2021
  • 1 location
Genome Sequencing of Human Cancer Tissues

The goal of this study is to develop a new, local system that will use special tests based on patients' genetic makeup to better tailor cancer care at the University of New Mexico Cancer Center. The Food and Drug Administration has already approved over forty (40) drugs to treat cancer …

cancer care
primary cancer
cancer treatment
  • 0 views
  • 21 May, 2021
  • 1 location
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

The purpose of this study is to test how well the drug works, safety and tolerability of an investigational drug called Ruxolitinib in gliomas and glioblastomas, when combined with standard treatment for brain cancer, temozolomide and radiation. Ruxolitinib is an experimental drug that works by targeting proteins in cells and …

anaplastic astrocytoma
astrocytoma
malignant brain tumor
oligodendroglioma, anaplastic
brain tumor
  • 41 views
  • 23 Mar, 2022
  • 2 locations
Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status (ARETHUSA)

In this study, MMRd metastatic colorectal cancer (mCRC) patients who failed standard therapies will undergo treatment with pembrolizumab, while RAS-extended mutated MMR-proficient mCRC patients will be tested for o6-methylguanine-DNA-methyltransferase (MGMT) expression (IHC) and then for MGMT promoter methylation. MGMT IHC-negative, promoter methylation positive patients will be treated with temozolomide (TMZ). …

irinotecan
aflibercept
metastatic colorectal cancer
metastasis
cetuximab
  • 0 views
  • 17 Feb, 2022
  • 4 locations
A Clinical Trial Evaluating the Efficacy of Valganciclovir in Glioblastoma Patients

This study is a multicenter randomized double-blinded controlled phase 2 study evaluating the efficacy and safety of the anti-CMV drug valganciclovir vs placebo as add-on therapy in patients with glioblastoma. Valganciclovir is approved for treatment of cytomegalovirus (CMV) infections, but may also have anti-tumoral effects. Current evidence imply that most …

temozolomide
  • 0 views
  • 22 Sep, 2021
  • 1 location
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC

The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in …

reflux
gastroesophageal reflux
esophageal adenocarcinoma
intramucosal adenocarcinoma
barrett's esophagus
  • 328 views
  • 31 Jul, 2021
  • 37 locations
Targeting DNA-methylation Fingerprints Linked to Ultra-Processed Foods Consumption to Prevent Non-communicable Diseases: the METHYL-UP Study (METHYL-UP)

Non-communicable diseases (NCD) are the main health challenge in industrialized countries. However, these diseases are preventable if an intervention based on lifestyle is implemented at the population level. Diet has a great impact on the onset and progression of NCD. In this regard, ultra-processed food (UPF) consumption has been related …

  • 0 views
  • 20 Apr, 2022
  • 1 location