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Found 75 clinical trials
DNA Methylation Testing for the Screening of Uterine Cervical Lesion

In our published work, host DNA methylation testing has been proved to be sensitive and specific to cervical intraepithelial neoplasia (CIN) 2 or more severe lesions (CIN2+). Its screening effects are independent of high-risk human papillomavirus (hrHPV) status. Based on the results of training and validation sets of our previous …

  • 0 views
  • 27 Jan, 2021
  • 1 location
An Extended Access Program for Bardoxolone Methyl in Patients With CKD (EAGLE) (EAGLE)

This extended access study will assess the long-term safety and tolerability of bardoxolone methyl in qualified patients with chronic kidney disease (CKD) who previously participated in one of the qualifying clinical studies with bardoxolone methyl. Patients will remain in the study until bardoxolone methyl is available through commercial channels or …

chronic kidney disease
nephropathy
renal failure
renal disease
  • 211 views
  • 15 Jun, 2022
  • 66 locations
A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON (FALCON)

This international, multi-center, randomized, double-blind, placebo-controlled Phase 3 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients with ADPKD. Approximately 850 patients will be enrolled.

diastolic blood pressure
systolic blood pressure
cyst
  • 341 views
  • 19 Jun, 2022
  • 132 locations
Temozolomide + Nivolumab in MGMT Methylated Oesophagogastric Cancer

An open label single arm phase II trial in patients with advanced unresectable previously treated oesophagogastric adenocarcinoma which is MGMT deficient.

nivolumab
adenocarcinoma
  • 0 views
  • 21 Oct, 2021
  • 1 location
Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

MGMT methylated glioblastoma. Chemotherapy drugs, such as lomustine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from

karnofsky performance status
methylated
temozolomide
tumor resection
flair
  • 0 views
  • 26 Apr, 2022
  • 34 locations
Ibrutinib With Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma

radiation combination therapy in methylated MGMT glioblastoma.

methylated
cancer
temozolomide
aptt
MRI
  • 109 views
  • 21 Mar, 2022
  • 1 location
Dendritic Cell Immunotherapy Against Cancer Stem Cells in Glioblastoma Patients Receiving Standard Therapy (DEN-STEM)

Open, randomized study of a trivalent dendritic cell therapy compared to standard therapy in primary treated patients with IDH wild-type, MGMT-promotor methylated glioblastoma. The IMP is

methylated
MRI
cancer
temozolomide
  • 115 views
  • 04 Mar, 2022
  • 1 location
Repurposing Chlorpromazine in the Treatment of Glioblastoma (RACTAC)

chemotherapy with temozolomide, in newly diagnosed glioblastoma multiforme patients carrying a hypo-methylated O6-methylguanine-DNA-methyltransferase (MGMT) gene

karnofsky performance status
methylated
temozolomide
  • 8 views
  • 24 Feb, 2022
  • 3 locations
Bevacizumab and Tocotrienol in Recurrent Ovarian Cancer

A recent study at the Department of Oncology, Vejle Hospital (NCT02399592), investigated bevacizumab and tocotrienol in ovarian cancer patients and concurrently monitored the level of methylated

  • 0 views
  • 24 May, 2022
  • 1 location
Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

of anti-PD-1 administration impacts the immunogenicity of NeoVax. An additional sub-study cohort (1d) is being added for patients whose tumor is MGMT-methylated. Cohort 1d will enroll

karnofsky performance status
methylated
cancer
temozolomide
aptt
  • 0 views
  • 17 Jun, 2022