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Found 13 clinical trials
Flow Cytometry Analysis of Eosinophils in Severe Asthma Patients.

Asthma is a heterogeneous disease, characterized by reversible airflow obstruction, airway hyperresponsiveness, and airway inflammation, in which 40% of patients exhibit eosinophil-driven pathobiology.The main treatment of asthma is the use of corticosteroid, whose use induces a reduction in eosinophils that is considered a strong predictor of response to treatment. Corticosteroids …

  • 0 views
  • 21 Aug, 2021
  • 1 location
A Feasibility Study of SenseGuard to Assess Airway Responsiveness During Methacholine Challenge Test (MCT)

SenseGuard (SG) is an innovative device for respiratory monitoring. At this study SG measurement will be integrated in a Methacholine Challenge Test (MCT) for monitoring changes in airway

  • 0 views
  • 17 Dec, 2021
  • 1 location
Dupilumab on Airway Hyper-responsiveness and Ventilation Heterogeneity in Patients With Asthma.

In asthmatics with airway hyperresponsiveness and a "T2 immune signature" (type 2), Dupilumab will suppress airway hyperresponsiveness (assessed by methacholine PC20 4 mg/mL (PC20: provocative

prednisone
fluticasone
bronchodilator
methacholine
nitric oxide
  • 0 views
  • 19 Sep, 2021
  • 1 location
Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes

secondary endpoints plasma L-arginine/ADMA, FEV1 and PC20 methacholine. Parallel to this study, a small study of 10 healthy obese controls will receive open label L-citrulline for 7 weeks to establish

Accepts healthy volunteers
  • 0 views
  • 18 Jan, 2022
  • 1 location
Increased Lung Volume as Controller Therapy for Asthma

This is an early phase clinical trial to test the efficacy of elevating lung volume with positive expiratory pressure (CPAP) as a controller therapy for asthma in patients with a BMI 30 kg/m2. There will be two phases to this trial. Phase I: In the first phase we will determine …

methacholine
  • 13 views
  • 19 Aug, 2021
  • 1 location
The Effect of Per Oral Immunotherapy in Severe Milk Peanut and Egg Allergy in Adults

The aim is to analyse the results of per oral immunotherapy treatment in severe milk, peanut or egg allergy in adults. This is the second part of the oral immunotherapy study in adults at Skin and Allergy Hospital. The diagnosis of food allergy is verified with positive history, skin prick …

prick skin
serum ige
milk allergy
egg allergy
allergen
  • 51 views
  • 26 Jan, 2021
  • 1 location
Obesity Metabolic Dysregulation and the Airway Epithelium in Asthmatics

The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology. To do so, the investigators want to determine how obesity and the metabolic syndrome relate to metabolism in bronchial airway epithelial cells and the …

body mass index
fasting
antihypertensive drugs
nitric oxide
pulmonary function test
  • 77 views
  • 30 Sep, 2021
  • 1 location
Structure and Function MRI of Asthma

The investigators will apply 129Xenon and/or 3He image acquisition and analysis methods in 120 asthma patient volunteers in order to characterize and probe the relationship between lung structure and function using imaging.

pulmonary function test
  • 101 views
  • 23 Jan, 2021
  • 1 location
Exercise Induced Bronchoconstriction and Field Tests

Asthma and exercise induced bronchoconstriction (EIB) represent an important challenge for the athlete, and correct diagnosis is important as it affects health as well as performance with strict regulations concerning asthma medication. The primary objective of this study on elite athletes with symptoms of EIB, is to assess if EIB …

  • 0 views
  • 27 Jan, 2021
  • 1 location
GSNOR Phenotyping/GSNO Challenge in Severe Asthma

Asthma is caused by or worsened by different things in different people. It is because of these differences that not all people with asthma respond the same to all treatments and medicines. If the investigators can better identify the changes in the airways or breathing pipes in patients with asthma, …

obstructive lung disease
atopy
methacholine
COPD
bronchodilator
  • 175 views
  • 26 Dec, 2021
  • 2 locations