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Found 11 clinical trials
Flow Cytometry Analysis of Eosinophils in Severe Asthma Patients.

Asthma is a heterogeneous disease, characterized by reversible airflow obstruction, airway hyperresponsiveness, and airway inflammation, in which 40% of patients exhibit eosinophil-driven pathobiology.The main treatment of asthma is the use of corticosteroid, whose use induces a reduction in eosinophils that is considered a strong predictor of response to treatment. Corticosteroids …

  • 0 views
  • 21 Aug, 2021
  • 1 location
Use of Buventol Easyhaler and Bufomix Easyhaler in Methacoline Challenge Testing (EASYRELIEF)

The study compares Buventol® Easyhaler® and Bufomix® Easyhaler® to the current standard treatment during methacholine challenge test. The trial will also provide inspiratory flow profile data

  • 6 views
  • 23 Mar, 2022
  • 1 location
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline

(CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough. We hypothesize

Accepts healthy volunteers
  • 11 views
  • 30 Apr, 2022
  • 1 location
Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes (SANDIA)

secondary endpoints plasma L-arginine/ADMA, FEV1 and PC20 methacholine. Parallel to this study, a small study of 10 healthy obese controls will receive open label L-citrulline for 7 weeks to establish

Accepts healthy volunteers
  • 0 views
  • 21 Mar, 2022
  • 1 location
Increased Lung Volume as Controller Therapy for Asthma

This is an early phase clinical trial to test the efficacy of elevating lung volume with positive expiratory pressure (CPAP) as a controller therapy for asthma in patients with a BMI ≥ 30 kg/m2. There will be two phases to this trial. Phase I: In the first phase we will …

methacholine
  • 13 views
  • 15 Jun, 2022
  • 1 location
Obesity Metabolic Dysregulation and the Airway Epithelium in Asthmatics

The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology. To do so, the investigators want to determine how obesity and the metabolic syndrome relate to metabolism in bronchial airway epithelial cells and the …

fasting
nitric oxide
asthma
airways disease
methacholine
  • 85 views
  • 30 Sep, 2021
  • 1 location
Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases (MUCOSA)

Cough is the most common presenting symptom to family physician. Chronic Cough affects approximately 10-12% of the general population and is one of the commonest reasons for referral to secondary care. Unfortunately, there are no licensed treatments for this debilitating condition, which is associated with a poor quality of life, …

  • 0 views
  • 25 Mar, 2022
  • 1 location
GSNOR Phenotyping/GSNO Challenge in Severe Asthma

Asthma is caused by or worsened by different things in different people. It is because of these differences that not all people with asthma respond the same to all treatments and medicines. If the investigators can better identify the changes in the airways or breathing pipes in patients with asthma, …

bronchodilator
COPD
atopy
methacholine
pulmonary disease
  • 176 views
  • 16 Mar, 2022
  • 2 locations
Treatment With the Anti-IgE Monoclonal Antibody Omalizumab in Women With Asthma Undergoing Fertility Treatment. - A Proof of Concept Study. (PRO_ART)

The investigators have previously confirmed a clinical hunch that women with asthma have difficulties in becoming pregnant. The investigators found increased time to pregnancy (TTP) in women with asthma compared to non-asthmatic women (55 vs 33 months, p<0.001), furthermore, women with asthma had less successful pregnancies following fertility treatment (39.6 …

allergic asthma
embryo transfer
atopy
anti-ige
intracytoplasmic sperm injection
  • 152 views
  • 25 Mar, 2022
Evaluate the Therapeutic Effect of Inhaled Corticosteroid in Asthmatic Children

Inhaled corticosteroid (ICS) is considered the first line medication for asthma, however, the therapeutic effect is markedly different even in patients with almost similar clinical manifestations. Our study was designed to explore the clinical and genetic factors that may influence the effectiveness of ICS in asthmatic children.

corticosteroids
budesonide
  • 0 views
  • 03 Mar, 2022
  • 1 location