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Found 197 clinical trials
Impact of Metformin on Immuno-virologic Parameters in HIV

Non-diabetic, aviremic HIV-infected individuals on antiretroviral therapy (ART) will be randomized to metformin therapy or to observation for 72 weeks. Primary objective is to assess change over

antiretroviral therapy
antiretroviral agents
hiv dna
  • 0 views
  • 24 Jan, 2021
Role of Metformin on Muscle Health of Older Adults

Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin

Accepts healthy volunteers
bed rest
insulin
  • 1 views
  • 07 Jul, 2022
  • 1 location
Study of Dabrafenib Trametinib and Metformin for Melanoma Patients

The main purpose is to evaluate the clinical response, safety and survival of the FDA approved drugs Dabrafenib, Trametinib in combination with Metformin. Investigators hypothesize that the

trametinib
measurable disease
cancer
metastatic melanoma
neutrophil count
  • 34 views
  • 04 Nov, 2021
  • 2 locations
Neoadjuvant Chemotherapy With or Without Metformin in Early Breast Cancer.

Metformin is a widely used anti-diabetic drug. Several studies have pointed out a potentially beneficial effect of metformin therapy in diabetic cancer patients. Several studies are

mammogram
breast carcinoma
metastasis
carcinoma
  • 0 views
  • 25 Jan, 2021
  • 1 location
Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) (TRIM-AF)

aims to determine if metformin and/or lifestyle/risk factor modifications reduce AF burden and progression. A secondary aim will attempt to determine clinical, genomic, and biomarker predictors of AF

paroxysmal atrial fibrillation
antiarrhythmic drug
hypertension
heart failure
fibrillation
  • 3 views
  • 13 Feb, 2022
  • 1 location
Effect of Metformin on Visual Function in Patients With Glaucoma

The purpose of this study is to determine whether Metformin could prevent the progression of glaucoma in a safe and effective manner.

ophthalmic solution
metformin
migraine
headache
primary open angle glaucoma
  • 6 views
  • 25 Mar, 2022
  • 1 location
Metformin Effect on Brain Function in Insulin Resistant Elderly People

Alzheimer's disease (AD) and other forms of dementia are rapidly increasing with the aging of the population, and show a clear preponderance among people with insulin resistance. Metformin, an

metformin
insulin resistance
insulin
Accepts healthy volunteers
fasting
  • 31 views
  • 04 Feb, 2022
  • 1 location
Acupuncture or Metformin for Insulin Resistance in Women With PCOS (PIAII)

The hypothesis is that acupuncture is equally effective as metformin (both treatments combined with lifestyle management) in improving whole body glucose homeostasis in insulin resistant women

insulin resistance
cancer
hirsutism
transvaginal ultrasound
acne
  • 717 views
  • 02 Jul, 2022
  • 2 locations
CS02 vs Placebo With Metformin in Type 2 Diabetic Subjects

The objective of the study is to compare the efficacy and safety of 3 doses CS02 Tablet in combination with a stable dose of metformin monotherapy against CS02 PTM (placebo) Tablet in

  • 14 views
  • 08 Nov, 2020
  • 2 locations
Calorie Restriction With or Without Metformin in Triple Negative Breast Cancer

Glucose starvation and metformin have synergistic antitumor effects that are mediated through the concomitant inhibition of glycolysis and mitochondrial oxidative phosphorylation. The BREAKFAST

taxane
triple negative breast cancer
doxorubicin
paclitaxel
progesterone
  • 34 views
  • 25 Jan, 2021
  • 1 location