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Found 198 clinical trials
Antecedent Metabolic Health and Metformin Aging Study (ANTHEM)

Aging is the number one risk factor for the majority of chronic diseases. There are no pharmaceutical treatments to slow aging and prolong healthspan. The anti-diabetic drug metformin is

muscle biopsy
diabetes
Accepts healthy volunteers
a 12
metformin
  • 196 views
  • 26 Feb, 2022
  • 2 locations
Metformin as RenoProtector of Progressive Kidney Disease (RenoMet)

A multi-center, practice-oriented, repurposing, double-blinded, placebo-controlled, randomized clinical trial. The RenoMet trial is repurposing an already approved agent (Metformin , Glucophage

proteinuria
glomerular filtration rate
nephropathy
  • 2 views
  • 02 Mar, 2022
  • 9 locations
Oral Metformin for Treatment of ABCA4 Retinopathy

cells to die. The cell death can lead to vision loss. Researchers want to see if an oral drug called metformin can help. Objective To see if metformin is safe and

  • 8 views
  • 23 Jul, 2022
  • 1 location
Methotrexate and Metformin in Rheumatoid Arthritis Patients (METorMET²)

remission. Metformin is the first-line therapy for type 2 diabetes. Its antioxidative and anti-inflammatory properties make it a good candidate for the treatment of inflammatory diseases such as rheumatoid

diabetes
methotrexate
remission
methotrexate treatment
  • 0 views
  • 18 Apr, 2022
  • 6 locations
Effect of Metformin on Patients With Osteoarthritis

This randomized controlled trial aims to investigate if metformin has osteoarthritis protective effects among overweighted knee osteoarthritis patients. The co-primary outcomes are changes in

knee pain
body mass index
  • 0 views
  • 23 Mar, 2022
  • 1 location
MetfOrmin BenefIts Lower Extremities With Intermittent Claudication (MOBILE IC)

walking and poor quality of life. There is no effective medical treatment for PAD and IC. Metformin is a safe and effective treatment for Type 2 diabetes but it can also reduce inflammation, oxidative

  • 0 views
  • 28 Jul, 2022
  • 1 location
TEsting METformin Against Cognitive Decline in HD

Multicenter, randomized, double-blind, placebo-controlled, parallel group study to assess the efficacy and safety of metformin treatment at a dose of 1700 mg / day in adults with Huntington's

cognitive decline
  • 0 views
  • 23 Apr, 2022
  • 7 locations
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

This is a single-center trial in subjects with pancreatic cancer and other advanced solid tumors. It is an open-label, single arm dose escalation Phase IB trial with subjects accrued in a 3 subject dose escalation cohort. Subjects with treated advanced solid tumors, and showing disease progression on established standard therapy, …

serum pregnancy test
solid tumour
cancer
  • 8 views
  • 11 Feb, 2022
  • 1 location
Pregnancy Outcomes: Effects of Metformin Study (POEM Study) (POEM)

child (macrosomia, hypoglycaemia) with related adverse pregnancy outcomes. Metformin, as an insulin sensitizer targeting the cause of GDM, may have essential benefits, as suggested by observational

hemoglobin a1c
glucose tolerance test
insulin
diabetes
metformin
  • 0 views
  • 23 Mar, 2022
  • 4 locations
Role of Metformin on Muscle Health of Older Adults

Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin

bed rest
Accepts healthy volunteers
insulin
  • 1 views
  • 07 Jul, 2022
  • 1 location