Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 243 clinical trials
The Effect of Sitagliptin on Hypertension Arterial Stiffness Oxidative Stress and Inflammation

Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect of the incretin modulators drugs on hypertension, arterial stiffness, inflammation and oxidative stress parameters have not been fully investigated yet.GLP-1 analogue has been suggested to …

hypoglycemic agents
metformin
arterial stiffness
dipeptidyl peptidase-4 inhibitor
heart disease
  • 11 views
  • 07 Nov, 2020
  • 1 location
The Effect of Dapagliflozin on Platelet Function testinG Profiles in Diabetic PatiEnts.

Sodium GLucose Transport 2 inhibitors (SGLT2I), including dapagliflozin, reduce the likelihood of hospitalization for heart failure and death in persons with type 2 diabetes, of which the mechanism has not been fully elucidated. The mechanistic effects of dapagliflozin on platelet function profiles have not yet been ascertained. It remains unclear …

  • 0 views
  • 26 Jan, 2021
  • 1 location
"The Role of the Liver for Interorgan Metabolic Crosstalk in Type 2 Diabetes"

WP 1: Working hypothesis: The gluconeogenic flux rates from pyruvate (lactate, alanine) and glycerol are higher in patients with T2D compared to the healthy control group. WP2: Working Hypothesis: The gluconeogenic flux rates of lactate and glycerol are reduced in patients with T2D by acute inhibition of the redox shuttle.

  • 0 views
  • 23 Jan, 2021
  • 1 location
Effect of Cassia Cinnamon on Arterial Stiffness Parameters in Patients With Type 2 Diabetes Mellitus

Type 2 diabetes mellitus is considered a serious public health problem that has been raising worldwide. In Mexico, it is an important cause of morbi - mortality and its characterized by hyperglycemia that promotes an increase of cardiovascular risk through the impairment of arterial stiffness and endothelial function, which, in …

  • 0 views
  • 24 Jan, 2021
  • 1 location
Testosterone Therapy in Men With Low Testosterone Levels and Metabolic Syndrome or Early Stages of Type 2 Diabetes

Men with metabolic syndrome often have lower than normal testosterone levels and low testosterone levels have been suggested to predispose for development of type2 diabetes. The aim of the study is to evaluate if normalisation of serum testosterone levels in men with metabolic syndrome (Abdominal obesity, hypertension, dyslipidemia, insulin resistance …

oral glucose tolerance test
dyslipidemia
central obesity
insulin resistance
diabetes
  • 232 views
  • 07 Nov, 2020
  • 1 location
Diluted Insulin in Young Children: Bigger Volumes for Smaller Patients

The aim of this study is to compare the pharmacokinetic (PK) profile of diluted insulin aspart (U25) with undiluted insulin aspart (U100) in school-aged children and adolescents with type 1 diabetes (T1D) utilizing the euglycemic clamp technique and a standardized meal in a controlled research environment. The investigators hypothesize that …

  • 0 views
  • 23 Jan, 2021
Outpatient Treatment of COVID-19 With Metformin

The purpose of this trial is to conduct a Stage 1 Substudy powered to detect a difference in continuous laboratory outcomes: Test if metformin treatment in non-hospitalized adults

  • 0 views
  • 03 Mar, 2021
  • 1 location
Diabetes Prevention With Lifestyle Intervention and Metformin Escalation

: This study seeks to test the hypothesis that implementation of a lifestyle intervention, with escalation to Metformin therapy will lower the incidence of diabetes among the highest risk pre-diabetic

metformin
sugars
gestational diabetes
prediabetic state
hemoglobin a1c
  • 89 views
  • 23 Jan, 2021
  • 6 locations
SGLT2 Inhibitor or Metformin as Standard Treatment of Early Stage Type 2 Diabetes

A real-world, nationwide, register-based, randomised trial (RRCT) comparing SGLT2 inhibitors with metformin as standard treatment in early typ 2 diabetes. An open-label trial addressing efficacy

metformin
sglt2
sglt2 inhibitor
dapagliflozin
  • 22 views
  • 24 Jan, 2021
  • 1 location
Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs

A prospective, large, pragmatic, randomized trial to study the impact of METFORMIN and healthy lifestyle intervention (LIFE) vs. LIFE alone on patient-centered outcomes of body weight, SGA

aripiprazole
quetiapine
cariprazine
body mass index
clozapine
  • 212 views
  • 23 Jan, 2021
  • 30 locations