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Found 203 clinical trials
DANHEART (H-HeFT and Met-HeFT) (DANHEART)

The present study is testing in a combined design to types of drugs in patients with chronic heart failure: 1) Hydralazine in combination with isosorbide dinitrate (BiDil) and 2) Metformin

body mass index
insulin resistance
hydralazine
diabetes
glycosylated hemoglobin
  • 62 views
  • 03 Mar, 2022
  • 23 locations
Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)

This study will evaluate the safety and efficacy of ertugliflozin (MK-8835) in pediatric participants with T2DM on metformin with/without insulin. The primary hypothesis of the study is that the

body mass index
hemoglobin a1c
insulin
c-peptide
fasting
  • 506 views
  • 19 Jun, 2022
  • 73 locations
Repurposed Approved and Under Development Therapies for Patients With Early-Onset COVID-19 and Mild Symptoms

early-onset disease and mild symptoms. Experimental studies have demonstrated a potential anti-inflammatory role of Fluvoxamine, Metformin and Ivermectin in SARS-CoV-2 infections and observational

  • 0 views
  • 23 Mar, 2022
  • 12 locations
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE)

throughout the trial. New patients joining the trial from Protocol version 17.0 onwards (activated in December 2018) may be eligible to join one of two treatment comparisons, metformin (treatment group K

endocrine therapy
enzalutamide
prostate cancer metastatic
androgen suppression
testosterone
  • 3825 views
  • 04 May, 2022
  • 115 locations
Longitudinal Follow-up in Women With Endometrial Hyperplasia Without Atypia

weight control and be randomized 1:1 to with or without metformin intervention. At the end of this 3-year project, an interim analysis will be performed. Since long-term follow-up is intended, therefore

  • 0 views
  • 11 Apr, 2022
  • 1 location
To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

), inavolisib in combination with palbociclib and fulvestrant (Arm E), inavolisib in combination with palbociclib, fulvestrant, and metformin (Arm F), and inavolisib in combination with trastuzumab and

metastasis
letrozole
epidermal growth factor receptor
erbb2
growth factor
  • 96 views
  • 18 Jun, 2022
  • 12 locations
Pioglitazone and SGLT2 Inhibitors vs. DPP4 Inhibitors in Patients With Stroke

within 3 months, diabetes mellitus with Hba1C > 7%, taking metformin currently or previously, and estimated glomerular filtration rate ≥ 45 mL/min/1.73 m2. Eligible patients who sign the informed

dipeptidyl peptidase-4 inhibitor
insulin resistance
pioglitazone
hemoglobin a1c
diabetes mellitus
  • 0 views
  • 24 Mar, 2022
  • 1 location
A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE) (REALYSE)

people with type 2 diabetes. The purpose of the study is to see how well RYBELSUS® is at lowering blood sugar compared to other tablets when used in addition to metformin. Participants

  • 0 views
  • 06 Apr, 2022
  • 15 locations
Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

HYPOTHESIS: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) have distinct pathophysiologic etiologies. Therefore, therapeutic interventions designed to correct the specific underlying pathogenic abnormalities in IGT and IFG will be required to optimally prevent the progressive beta cell failure and development of overt type 2 diabetes.

saxagliptin
pioglitazone
impaired glucose tolerance
prediabetic state
dapagliflozin
  • 39 views
  • 27 Jan, 2022
  • 1 location
Optimal Nutrition for Prevention of Hypertension in Pregnancy

The aim of this study is to investigate the role of the 677CT polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene on blood pressure (BP) during pregnancy, and to examine the effect of intervention with riboflavin, alone or in combination with 5-methyltetrahydrofolate (5-MTHF), as a non-drug approach for managing BP in …

  • 0 views
  • 28 Jan, 2021
  • 3 locations