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Found 103 clinical trials
Tumor Subtypes in Subjects on FOLFIRINOX With Non-Metastatic Pancreatic Cancer

This is a research study to evaluate how the genetic makeup of Pancreatic Ductal Adenocarcinoma (PDAC) can affect the response to FDA-approved chemotherapy treatment, FOLFIRINOX, given before surgery to remove the tumor. Certain types of PDAC tumors can be surgically resected (removed). However, not all types of PDACs are resectable, …

folfirinox
pancreatic ductal adenocarcinoma
pancreatic adenocarcinoma
oxaliplatin
leucovorin
  • 10 views
  • 15 Jun, 2022
  • 1 location
Study of CRS-207, Pembrolizumab, Ipilimumab, and Tadalafil in Metastatic Pancreatic Cancer

The purpose of this study is to evaluate the safety and clinical activity of tadalafil, pembrolizumab, ipilimumab, and CRS-207 in subjects with metastatic pancreatic adenocarcinoma who have progressed after at least 1 prior chemotherapy regimen.

adenocarcinoma
cancer chemotherapy
metastatic pancreatic cancer
ipilimumab
pancreatic adenocarcinoma
  • 0 views
  • 12 Jul, 2022
  • 1 location
Binimetinib and Hydroxychloroquine in Treating Patients With KRAS Mutant Metastatic Pancreatic Cancer

This phase I trial studies the best dose of hydroxychloroquine when given together with binimetinib in treating patients with KRAS gene mutated pancreatic cancer that has spread to other places in the body (metastatic). Binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for …

  • 0 views
  • 20 Jul, 2022
  • 1 location
Timing of Start of systemIc Treatment for Asymptomatic Metastasized Pancreatic Cancer

Since patients with metastatic pancreatic cancer have a limited life expectancy, it is important to determine the timing of when to start chemotherapy in order to optimize the benefits of

  • 0 views
  • 31 May, 2021
  • 1 location
INCMGA00012 in Patients With Previously Treated Unresectable or Metastatic Adenosquamous Pancreatic or Ampullary Cancer

Phase 2 study to evaluate the clinical activity of INCMGA00012 in patients with Unresectable or metastatic Adenosquamous Pancreatic or Ampullary Cancer.

cancer
measurable disease
antiretroviral therapy
  • 0 views
  • 11 Mar, 2022
  • 1 location
Safety Study of Whole Body Hyperthermia for Advanced Cancer (MATTERS)

Millions of patients die of cancer every year. There are several methods to treat cancer, including surgery, chemotherapy, radiotherapy and immunotherapy. Recently, hyperthermia therapy started playing a role in cancer therapy. It has shown effect in animal experiments and clinical practice. The sponsor has developed a novel device to use …

  • 0 views
  • 15 May, 2022
  • 1 location
Paricalcitol and Hydroxychloroquine in Combination With Gemcitabine and Nab-Paclitaxel for the Treatment of Advanced or Metastatic Pancreatic Cancer

This phase II trial investigates how well paricalcitol and hydroxychloroquine work when combined with gemcitabine and nab-paclitaxel in treating patients with pancreatic cancer that has spread to other places in the body (advanced or metastatic). Paricalcitol (a form of vitamin D) works by blocking a signal in the cancer cells …

chemotherapy drug
calcium
ct scan
international normalized ratio
aptt
  • 0 views
  • 05 Mar, 2021
  • 3 locations
PANFIRE-3 Trial: Assessing Safety and Efficacy of Irreversible Electroporation (IRE) + Nivolumab + CpG for Metastatic Pancreatic Cancer

Irreversible electroporation is a local ablative technique used in the treatment of pancreatic cancer. In addition to its cytoreductive ability, IRE also induces a systemic immune response. However, this immune response is not potent enough to establish durable regression of the tumor. The immune response can be leveraged by combining …

folfirinox
biliary obstruction
metastasis
nivolumab
monoclonal antibodies
  • 3 views
  • 26 Jan, 2021
  • 1 location
Niraparib and Dostarlimab for the Treatment of Germline or Somatic BRCA1/2 and PALB2 Mutated Metastatic Pancreatic Cancer

This phase II trial studies how well niraparib and dostarlimab work in treating patients with germline or somatic BRCA1/2 and PALB2 mutated pancreatic cancer that has spread to other places in the body (metastatic). Niraparib may stop the growth of tumor cells by blocking some of the enzymes needed for …

  • 0 views
  • 25 Jul, 2022
  • 3 locations
Efficacy and Safety of Dronabinol in the Improvement of Chemotherapy-induced and Tumor-related Symptoms in Advanced Pancreatic Cancer

patients with metastatic pancreatic cancer for improvement of chemotherapyand tumor-related symptoms applicated by individual titration up to the maximum tolerated dose.

abraxane
adjuvant therapy
folfirinox
cancer
gemcitabine
  • 2 views
  • 21 Mar, 2022
  • 10 locations