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Found 514 clinical trials
Yttrium-90 Radiation Lobectomy: Dose Optimization and Prediction of FLR Hypertrophy to Enable Resection of HCC

HCC resection candidates with inadequate future liver remnant will be enrolled in this study. They will be treated with Y90 radioembolization to help grow the liver enough to undergo liver resection. There will be 2 Patient Groups. The first group of patients will be treated with Y90 dose and embolic …

liver disease
hepatectomy
radioembolization
cirrhosis
  • 0 views
  • 12 Oct, 2022
  • 1 location
Biomarkers of Immune-Related Toxicity

This is a single-center, correlative pilot study evaluating potential biomarkers predictive of immune-related adverse events associated with immune checkpoint inhibitor therapy.

ipilimumab
primary cancer
atezolizumab
pembrolizumab
solid tumor
  • 46 views
  • 04 Oct, 2022
  • 1 location
Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer

xenografts representing the different subgroups of tumors for head and neck cancer perform genetic and transcriptional profiling of the primary, metastatic tumors and xenograft tumors

metastasis
cancer
neck cancer
head and neck cancer
  • 6 views
  • 27 Mar, 2021
  • 1 location
Genomic Profiling in Recommending Treatment for Patients With Metastatic Solid Tumors

This research trial studies using genomic profiling to recommend anticancer treatment to patients with cancer that has spread beyond the original site of the tumor (metastatic cancer). Genomic

metastasis
solid tumour
cancer
  • 1 views
  • 07 Oct, 2022
  • 2 locations
Hepatic Resection for Metastatic Pancreatic Cancer

The purpose of this study is to demonstrate the feasibility of an aggressive multimodal approach among patients with stage IV pancreatic cancer (PAC) with isolated, low-volume hepatic metastasis (LVHM). We will evaluate and describe the surgical and overall outcomes of an initial cohort of subjects who undergo pancreatectomy and hepatic …

metastatic pancreatic cancer
pancreaticoduodenectomy
pancreatectomy
hepatectomy
cancer
  • 34 views
  • 23 Mar, 2022
  • 1 location
Immune Resistance Interrogation Study (IRIS)

This is a prospective research study which will include patients who have progressed on immunotherapy as their most recent line of therapy. This study aims to characterize whether patients who fail to respond to immunotherapy versus patients who respond initially but after a period of time progress demonstrate different genomic, …

combination therapy
pd-l1
cancer
  • 0 views
  • 02 May, 2022
  • 1 location
Prevention and Treatment of Complications of Endovascular Methods in Patients With Malignant Liver Tumors

In the structure of malignant liver lesions, two main groups are distinguished - primary liver cancer and metastatic liver damage. The five-year survival rate of patients with malignant liver tumors does not exceed 6%. The main and radical method of treatment today is liver resection. However, surgical treatment is possible …

  • 0 views
  • 02 Mar, 2021
  • 1 location
The Role Of Circulating Tumor Cells As Markers Of Advanced Disease And Prognosis In HCC

Hepatocellular carcinoma (HCC) recurs in up to 60% of patients who undergo resection. Circulating tumor cells (CTC) have been advocated as promotors of the recurrence. However, their role as prognostic markers in the surgical setting is unclear. The aim of the present study has been to assess the association between …

  • 0 views
  • 23 Mar, 2021
  • 4 locations
18F-Fluciclovine PET Discrimination of Radiation Injury to the Brain

This phase I trial studies the ability and amount of fluciclovine positron emission tomography (PET) imaging needed to recognize tumors that have come back (recurrence) after brain injury from radiation therapy (radionecrosis) in patients with intracranial disease that has spread to other places in the body (metastatic). F-18 fluciclovine is …

  • 0 views
  • 14 Oct, 2022
  • 1 location
The Impact of DNA Repair Pathway Alterations Identified by Circulating Tumor DNA on Sensitivity to Radium-223 in Bone Metastatic Castration-Resistant Prostate Cancer

This phase II study investigates how well radium-223 works in treating patients with castration-resistant prostate cancer than has spread to the bones (bone metastases). Prostate cancer is the most common cancer in men and the second leading cause of cancer death. Furthermore, many men with notably advanced disease have been …

testosterone
metastatic castration-resistant prostate cancer
prostate specific antigen
dna damage
castration-resistant prostate cancer
  • 0 views
  • 27 Oct, 2022
  • 3 locations