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Found 500 clinical trials
Anamorelin Study for Advanced Pancreatic Cancer

Multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of anamorelin HCl. Approximately 100 subjects with advanced PDAC and cachexia will be randomized 1:1 to anamorelin HCl 100 mg or placebo, taken orally once daily (QD) for a total of 25 weeks. Subjects will be instructed to take …

  • 0 views
  • 24 Mar, 2022
  • 1 location
Study of Intra-Arterial Oxaliplatin Plus Capecitabine to Treat Liver Metastases From Colorectal Cancer

The treatment proposed in this trial is to administer intra-arterial chemotherapy to liver metastases from colorectal cancer when the blood flow to and from the liver has been isolated via balloon catheters through a vascular access system called the AVAS. The objective of this study is to evaluate the tumour …

  • 0 views
  • 08 Nov, 2021
  • 3 locations
A Study of Toripalimab or Combining With Temozolomide iv in the Treatment of Advanced/Metastatic Malignant Melanoma

This study evaluate toripalimab or combining with temozolomide for injection in the treatment of advanced/metastatic malignant melanoma. Participants in arm A receive toripalimab, in arm B receive toripalimab plus temozolomide

braf v600e mutation
temozolomide
BRAF
systemic therapy
  • 2 views
  • 24 May, 2021
  • 1 location
An Open-label, Multicenter, Multicohort, Phase 2 Study to Evaluate Enfortumab Vedotin in Subjects With Previously Treated Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)

The primary purpose of this study is to determine the antitumor activity of enfortumab vedotin as measured by confirmed objective response rate (ORR). This study will also assess other measures of antitumor activity; overall survival (OS); as well as the safety and tolerability of enfortumab vedotin.

  • 111 views
  • 23 Sep, 2022
  • 46 locations
A Study of Bispecific Antibody MCLA-145 in Patients With Advanced or Metastatic Malignancies

metastatic malignancies

metastasis
lymphoma
cancer
targeted therapy
mcla-145
  • 10 views
  • 09 Jun, 2022
  • 10 locations
Single-Fraction SBRT Versus Standard Palliative Radiation Therapy in Treating Patients With Metastatic Cancer

This phase II trial studies how well single-fraction stereotactic body radiation therapy (SBRT) works when compared to standard radiation therapy in treating patients with cancer that has spread to other places in the body (metastatic). Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to …

metastasis
tumor cells
cancer
  • 0 views
  • 09 May, 2022
  • 3 locations
A Phase II Randomized Study Evaluating Molecular Profiling and Targeted Therapy in Patients With Metastatic Cancer

genetic changes that are associated with cancer in a patient's tumor is a better way to treat patients with metastatic cancer compared to therapy not based on studying the genetic changes that are

metastasis
measurable disease
cancer
carcinoma
brain metastases
  • 20 views
  • 25 May, 2022
  • 1 location
Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Metastatic Cancer Patients

This study aims to determine if web-based eHealth delivery of pre-test and/or post-test counseling in cancer patients and/or those at risk for cancer can provide equal or improved cognitive and affective outcomes when compared to the standard of care delivery model.

Accepts healthy volunteers
genetic testing
breast cancer
metastasis
stage iv breast cancer
  • 0 views
  • 28 Oct, 2021
  • 1 location
Measurement and Characterization of Circulating Endothelial Cells or Circulating Tumor Cells or Circulating DNA in Adult Patients With Metastatic Cancer

Monitoring of circulating endothelial cells (CEC and mature cells called progenitors called CEP) or circulating tumor cells (CTC) in adult patients with metastatic cancer, possibly treated with

metastasis
tumor cells
cancer
metastatic solid tumor
targeted therapy
  • 7 views
  • 21 Jan, 2021
  • 1 location
Safety and Pharmacokinetics (PK) of Escalating Doses of Tiragolumab as a Single Agent and in Combination With Atezolizumab and/or Other Anti-Cancer Therapies in Locally Advanced or Metastatic Tumors

This first-in-human open-label, multicenter, dose-escalation and expansion study is designed to evaluate the safety, tolerability, and PK of tiragolumab alone or in combination with atezolizumab and/or other anti-cancer therapies in participants with locally advanced, recurrent, or metastatic incurable tumors for whom standard therapy does not exist, has proven to be …

  • 4 views
  • 23 Jul, 2022
  • 26 locations