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Found 28 clinical trials
Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer

This phase II trial studies how well savolitinib works in treating patients with MET amplified colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Savolitinib may stop the growth of tumor cells by blocking some of the enzymes needed for …

neutrophil count
cetuximab
tumor cells
bevacizumab
pembrolizumab
  • 24 views
  • 18 Feb, 2021
  • 30 locations
Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer

This randomized pilot clinical trial studies health care coach support in reducing acute care use and cost in patients with cancer. Health care coach support may help cancer patients to make decisions about their care that matches what is important to them with symptom management.

neck cancer
myelodysplastic syndrome (mds)
breast cancer
lung cancer
head and neck cancer stage iii
  • 36 views
  • 23 Jan, 2021
  • 1 location
Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer

This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). 'Metastatic' means that the cancer has spread to other parts of the body. In the first part of this study, …

vascular endothelial growth factor
HER2
cancer
aflibercept
irinotecan
  • 308 views
  • 26 Jan, 2021
  • 61 locations
Panitumumab Regorafenib or TAS-102 in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer

This phase II trial studies how well retreatment with panitumumab works compared to standard of care regorafenib or trifluridine and tipiracil hydrochloride (TAS-102) in treating patients with colorectal cancer that is negative for RAS wild-type colorectal cancer has spread to other places in the body (metastatic), and/or cannot be removed …

  • 32 views
  • 23 Feb, 2021
  • 17 locations
LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer

This phase Ib/II trial investigates the side effects and best dose of LY3214996 when given together with cetuximab alone or in combination with abemaciclib and to see how well they work in treating patients with colorectal cancer that cannot be removed by surgery (unresectable) and/or has spread to other places …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Evolution of the Physical Condition in Treated Cancer Patients

Adaptated Physical Activity (APA) during treatment of cancer is one of the actual global health recommendation because of the benefits observed in several parameters evaluated in many clinical studies. A best knowledge of the physical and medical characteristics of patients, including type of cancer and type of treatment, is primordial …

breast cancer
lung metastases
cancer
taxane
folfox regimen
  • 0 views
  • 24 Jan, 2021
  • 1 location
ZETA : Prospective Observational Study

Primary objective Evaluate the efficacy in terms of progression-free survival (PFS) of aflibercept in combination with FOLFIRI in patients treated routinely for metastatic colorectal cancer (mCRC) after failure of treatment with oxaliplatin + EGFR. Secondary objective Evaluate the efficacy of aflibercept in combination with FOLFIRI on the 2-year overall survival …

cancer
oxaliplatin
metastatic colorectal cancer
aflibercept
EGFR
  • 16 views
  • 22 Jan, 2021
  • 2 locations
Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal Cancer for a COLOMATE Trial

This trial screens patients with colon or rectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) for genetic mutations for recommendation to a molecularly assigned therapy. Identifying gene mutations may help patients enroll onto target companion trials that target these …

  • 0 views
  • 24 Feb, 2021
  • 14 locations