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Found 26 clinical trials
Panitumumab Regorafenib or TAS-102 in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer

This phase II trial studies how well retreatment with panitumumab works compared to standard of care regorafenib or trifluridine and tipiracil hydrochloride (TAS-102) in treating patients with colorectal cancer that is negative for RAS wild-type colorectal cancer has spread to other places in the body (metastatic), and/or cannot be removed …

  • 32 views
  • 03 Jun, 2021
  • 17 locations
LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer

This phase Ib/II trial investigates the side effects and best dose of LY3214996 when given together with cetuximab alone or in combination with abemaciclib and to see how well they work in treating patients with colorectal cancer that cannot be removed by surgery (unresectable) and/or has spread to other places …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Evolution of the Physical Condition in Treated Cancer Patients

Adaptated Physical Activity (APA) during treatment of cancer is one of the actual global health recommendation because of the benefits observed in several parameters evaluated in many clinical studies. A best knowledge of the physical and medical characteristics of patients, including type of cancer and type of treatment, is primordial …

taxane
cancer
lung metastases
breast cancer
adjuvant chemotherapy
  • 0 views
  • 24 Jan, 2021
  • 1 location
ZETA : Prospective Observational Study

Primary objective Evaluate the efficacy in terms of progression-free survival (PFS) of aflibercept in combination with FOLFIRI in patients treated routinely for metastatic colorectal cancer (mCRC) after failure of treatment with oxaliplatin + EGFR. Secondary objective Evaluate the efficacy of aflibercept in combination with FOLFIRI on the 2-year overall survival …

aflibercept
oxaliplatin
cancer
metastatic colorectal cancer
EGFR
  • 16 views
  • 22 Jan, 2021
  • 2 locations
Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal Cancer for a COLOMATE Trial

This trial screens patients with colon or rectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) for genetic mutations for recommendation to a molecularly assigned therapy. Identifying gene mutations may help patients enroll onto target companion trials that target these …

  • 0 views
  • 30 May, 2021
  • 17 locations
Cetuximab Sensitivity Correlation Between Patient-Derived Organoids and Clinical Response in Colon Cancer Patients.

Eighty patients with RAS/RAF wild-type metastatic right colon cancer will be enrolled and undergo a fresh biopsy of tumor lesion before the standard treatment of chemotherapy. The investigators will establish organoids from the pre-treatment biopsies. Organoids will be exposed to the chemotherapy drugs or chemotherapy drugs combined with cetuximab used …

cetuximab
fluorouracil
oxaliplatin
cancer
irinotecan
  • 0 views
  • 15 Jun, 2021
  • 1 location