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Found 28 clinical trials
SGM-101 in Colorectal Lung Metastases

Near-infrared fluorescence-guided oncologic surgery (FGOS) with the use of a tumor specific tracer (SGM-101) developed by Surgimab can provide valuable intra-operative information about tumor location and extensiveness. SGM-101 already proven to be safe and valuable in colorectal cancer. This study aims to prove feasibility for colorectal lung metastases.

  • 0 views
  • 13 Feb, 2021
  • 2 locations
Phase 1b Study to Evaluate ATP128 With or Without BI 754091 in Patients With Stage IV Colorectal Cancer

This is a multi-center, non-randomised Phase 1b study to evaluate the safety and tolerability of ATP128 alone or in combination with BI 754091. ATP128 is a self-adjuvanted chimeric recombinant protein vaccine being developed in combination with programmed cell death 1 (PD-1) blockade for the treatment of microsatellite stable (MSS) patients …

absolute neutrophil count
stage iv colorectal cancer
neuropathy
gilbert's syndrome
neutrophil count
  • 12 views
  • 13 Feb, 2021
  • 6 locations
Encorafenib Binimetinib and Nivolumab in Treating Patients With Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer

This phase I/II trial studies the side effects and how well encorafenib, binimetinib, and nivolumab work in treating patients with microsatellite stable, BRAFV600E gene-mutated colorectal cancer that has spread to other places in the body (metastatic). Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of …

absolute neutrophil count
solid tumors
hysterectomy
monoclonal antibody therapy
investigational drug
  • 32 views
  • 26 Jan, 2021
  • 2 locations
Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites

The study designed is to evaluate the safety of Canady Helios Cold Plasma Scalpel (CHCPS) in patients with solid tumors with carcinomatosis scheduled to undergo surgical resection for cytoreduction. Patients with stage 4 resectable tumors as decided by a multidisciplinary disease management team may be included if the metastatic disease …

liver metastasis
absolute neutrophil count
neutrophil count
platelet count
cytoreduction
  • 4 views
  • 23 Jan, 2021
  • 1 location
M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

This phase Ib/II trial studies how well anti-PD-L1/TGFbetaRII fusion protein M7824 (M7824) works in treating patients with colorectal cancer (or with other solid tumors with microsatellite instability) that has spread to other places in the body or cannot be removed by surgery. Immunotherapy with monoclonal antibodies, such as M7824, may …

absolute neutrophil count
blood transfusion
monoclonal antibody therapy
cancer
metastasis
  • 118 views
  • 03 Feb, 2021
  • 2 locations
A Study to Assess PV-10 Chemoablation of Cancer of the Liver

The purpose of this study is to investigate the relationship between gut microbiome (bacteria in the gut), inflammation and the injured brain. It has been established that bacteria in the gut play key roles in digestion, nutrition absorption and immune response of the entire body. Human intestinal bacteria composition in …

spiral computed tomography
tumor growth
karnofsky performance status
renal function
platelet count
  • 170 views
  • 23 Jan, 2021
  • 6 locations
A Multi-Center Open-Label Study of Fruquintinib in Solid Tumors Colorectal and Breast Cancer

An open-label, dose escalation and expansion clinical trial to evaluate the safety, tolerability, and PK of fruquintinib in patients with advanced solid tumors, metastatic colorectal cancer and metastatic breast cancer.

erbb2
regorafenib
solid tumors
irinotecan
tumors, colorectal
  • 12 views
  • 17 Feb, 2021
  • 10 locations
S1613 Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2/neu amplified colorectal cancer that has spread from where it started to other places in the body and cannot be removed by surgery. Monoclonal antibodies, such as trastuzumab …

her-2
brain metastases
panitumumab
KRAS
monoclonal antibody therapy
  • 419 views
  • 28 Jan, 2021
  • 817 locations
Regorafenib Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer

This phase I trial studies the side effects and best dose of regorafenib when given together with ipilimumab and nivolumab in treating patients with microsatellite stable colorectal cancer that has spread to other places in the body (metastatic) and remains despite chemotherapy treatment (resistant). Regorafenib may stop the growth of …

  • 94 views
  • 28 Jan, 2021
  • 1 location
TAS-102 Irinotecan and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer the TABAsCO Study

This phase II trial studies how well TAS-102, irinotecan, and bevacizumab work in treating patients with pre-treated colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Drugs used in chemotherapy, such as TAS-102, work in different ways to stop the …

  • 1 views
  • 24 Feb, 2021
  • 3 locations