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Found 26 clinical trials
SGM-101 in Colorectal Lung Metastases

Near-infrared fluorescence-guided oncologic surgery (FGOS) with the use of a tumor specific tracer (SGM-101) developed by Surgimab can provide valuable intra-operative information about tumor location and extensiveness. SGM-101 already proven to be safe and valuable in colorectal cancer. This study aims to prove feasibility for colorectal lung metastases.

  • 0 views
  • 13 Feb, 2021
  • 2 locations
Phase 1b Study to Evaluate ATP128 With or Without BI 754091 in Patients With Stage IV Colorectal Cancer

This is a multi-center, non-randomised Phase 1b study to evaluate the safety and tolerability of ATP128 alone or in combination with BI 754091. ATP128 is a self-adjuvanted chimeric recombinant protein vaccine being developed in combination with programmed cell death 1 (PD-1) blockade for the treatment of microsatellite stable (MSS) patients …

gilbert's syndrome
stage iv colorectal cancer
measurable disease
oxaliplatin
immunohistochemistry
  • 12 views
  • 13 Feb, 2021
  • 6 locations
M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

This phase Ib/II trial studies how well anti-PD-L1/TGFbetaRII fusion protein M7824 (M7824) works in treating patients with colorectal cancer (or with other solid tumors with microsatellite instability) that has spread to other places in the body or cannot be removed by surgery. Immunotherapy with monoclonal antibodies, such as M7824, may …

liver metastases
measurable disease
international normalized ratio
platelet count
absolute neutrophil count
  • 118 views
  • 03 Feb, 2021
  • 2 locations
A Study to Assess PV-10 Chemoablation of Cancer of the Liver

This open-label study will evaluate the safety, tolerability, pharmacokinetics and effect on tumor growth following a single intralesional injection of PV-10 in subjects with either (a) hepatocellular carcinoma (HCC) that is not amenable to resection, transplant or other potentially curative therapy or (b) cancer metastatic to the liver.

renal function test
measurable disease
renal function
platelet count
spiral computed tomography
  • 170 views
  • 25 May, 2021
  • 6 locations
A Multi-Center Open-Label Study of Fruquintinib in Solid Tumors Colorectal and Breast Cancer

An open-label, dose escalation and expansion clinical trial to evaluate the safety, tolerability, and PK of fruquintinib in patients with advanced solid tumors, metastatic colorectal cancer and metastatic breast cancer.

erbb2
stage iv breast cancer
vascular endothelial growth factor
biological therapy
EGFR
  • 12 views
  • 17 Feb, 2021
  • 10 locations
S1613 Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2/neu amplified colorectal cancer that has spread from where it started to other places in the body and cannot be removed by surgery. Monoclonal antibodies, such as trastuzumab …

metastatic disease
hypertension
measurable disease
absolute neutrophil count
infarction
  • 419 views
  • 20 May, 2021
  • 830 locations
Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer

This phase II trial studies how well savolitinib works in treating patients with MET amplified colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Savolitinib may stop the growth of tumor cells by blocking some of the enzymes needed for …

fluorouracil
pembrolizumab
monoclonal antibodies
aflibercept
capecitabine
  • 24 views
  • 13 Jun, 2021
  • 30 locations
SX-682 and Nivolumab for the Treatment of RAS-Mutated MSS Unresectable or Metastatic Colorectal Cancer the STOPTRAFFIC-1 Trial

This phase Ib/II trial studies the side effects and best dose of SX-682 that can be given alone and in combination with nivolumab in treating patients with RAS-Mutated, microsatellite stable (MSS) colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). …

  • 0 views
  • 04 Mar, 2021
18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases

This early phase I trial tests the use of a radioactive tracer (a drug that is visible during an imaging test) known as 18F-FMAU, for imaging with positron emission tomography/computed tomography (PET/CT) in patients with brain cancer or cancer that has spread to the brain (brain metastases). A PET/CT scan …

  • 0 views
  • 28 Mar, 2021
  • 1 location
TAS-102 Irinotecan and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer the TABAsCO Study

This phase II trial studies how well TAS-102, irinotecan, and bevacizumab work in treating patients with pre-treated colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Drugs used in chemotherapy, such as TAS-102, work in different ways to stop the …

  • 1 views
  • 24 May, 2021
  • 4 locations