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Found 9 clinical trials
Natalizumab in Recurrent, Refractory or Progressive Pulmonary Metastatic Osteosarcoma

The purpose of this study is to evaluate the safety and tolerability of Natalizumab in children, adolescent and young adult patients with pulmonary metastatic osteosarcoma (pOS) and to assess

  • 0 views
  • 16 Jun, 2022
  • 1 location
A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas (REGOBONE)

INDICATION Metastatic bone sarcomas: conventional high grade osteosarcoma, Ewing sarcoma of bone, intermediate or high-grade chondrosarcomas and chordomas and

metastasis
sarcoma of bone
immunomodulators
ewing's sarcoma
measurable disease
  • 42 views
  • 27 Apr, 2022
  • 18 locations
Mifamurtide Combined With Post-operative Chemotherapy for Newly Diagnosed High Risk Osteosarcoma Patients (SARCOME13)

high-risk osteosarcoma (defined as metastatic osteosarcoma at diagnosis or localised osteosarcoma with poor histological response).

mifamurtide
metastasis
schwartz
etoposide
ifosfamide
  • 12 views
  • 14 Feb, 2022
  • 6 locations
BIO-11006 for Osteosarcoma and Ewing's Sarcoma Lung Metastases

This is a Phase 2 study of an investigational drug, BIO-11006, for the treatment of lung metastases in pediatric patients with advanced osteosarcoma or Ewing's sarcoma. This study will enroll up to 10 patients aged between 5 and 21 at Nicklaus Children's Hospital in Miami, FL. Patients will receive BIO-11006 …

  • 0 views
  • 30 May, 2022
  • 1 location
SARC038: Phase 2 Study of Regorafenib and Nivolumab in Osteosarcoma

A phase 2 study of regorafenib in combination with nivolumab in patients with refractory or recurrent osteosarcoma.

monoclonal antibodies
immunomodulators
hematopoietic growth factors
progressive disease
pegfilgrastim
  • 0 views
  • 07 Oct, 2022
  • 8 locations
A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large …

localized disease
methotrexate
systemic therapy
cancer
doxorubicin
  • 0 views
  • 16 Oct, 2022
  • 52 locations
Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Soft Tissue or Bone Sarcoma Metastatic to the Lungs

This phase I/II trial studies the side effects of pulmonary suffusion in controlling minimal residual disease in patients with soft tissue or bone sarcoma that has spread to the lungs. Pulmonary suffusion is a minimally invasive delivery of chemotherapeutic agents like cisplatin to lung tissues. Drugs used in chemotherapy, such …

isolated chemotherapeutic lung perfusion
sarcoma
metastasectomy
measurable disease
antineoplastic
  • 0 views
  • 04 Oct, 2022
  • 1 location
Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in Patients With Relapsed or Refractory Neuroblastoma or Relapsed Osteosarcoma

This phase I trial is to find out the best dose, possible benefits and/or side effects of magrolimab in combination with dinutuximab in treating patients with neuroblastoma that has come back (relapsed) or does not respond to treatment (refractory) or relapsed osteosarcoma. Magrolimab and dinutuximab are monoclonal antibodies that may …

  • 0 views
  • 07 Oct, 2022
  • 6 locations
Dietary Habits Metabolome Immune Profile and Microbiota in Patients With Bone Sarcoma

from metastatic osteosarcoma cells compared to primary tumor osteosarcoma cells. The effect of the intestinal microbiota into the metabolism of nutrients, drugs, inflammation, epigenetic and immune

  • 0 views
  • 11 Apr, 2021
  • 7 locations