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Found 14 clinical trials
FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation

Single-arm, multi-centre phase II study The primary objective is to evaluate the time to failure of the strategy.

metastasis
adjuvant chemotherapy
fluoropyrimidine
colorectal adenocarcinoma
panitumumab
  • 19 views
  • 05 Mar, 2021
  • 47 locations
Bevacizumab and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as irinotecan, fluorouracil, and capecitabine, work in …

metastasis
capecitabine
monoclonal antibodies
bevacizumab
fluorouracil
  • 5 views
  • 07 Nov, 2020
  • 1 location
Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer

This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). 'Metastatic' means that the cancer has spread to other parts of the body. In the first part of this study, …

HER2
oxaliplatin
trastuzumab
capecitabine
bevacizumab
  • 308 views
  • 17 Sep, 2021
  • 81 locations
Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases

colorectal adenocarcinoma with lung metastases.

metastasis
cancer
metastatic colorectal cancer
complete resection
neutrophil count
  • 4 views
  • 10 May, 2021
  • 7 locations
  • 0 views
  • 25 Jan, 2021
  • 1 location
Study of Pembrolizumab Binimetinib and Bevacizumab in Patients With Refractory Colorectal Cancer

This is an open-label, single-center, single-arm phase II clinical trial evaluating the combination of pembrolizumab, binimetinib, and bevacizumab in patients with metastatic colorectal

metastasis
bone metastases
bevacizumab
pembrolizumab
measurable disease
  • 19 views
  • 03 Mar, 2021
  • 1 location
Combination Chemotherapy Bevacizumab and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer the COMMIT Study

This phase III trial studies how well combination chemotherapy, bevacizumab, and/or atezolizumab work in treating patients with deficient deoxyribonucleic acid (DNA) mismatch repair colorectal cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as fluorouracil, oxaliplatin, and leucovorin calcium, work in different ways to stop …

  • 460 views
  • 19 Sep, 2021
  • 337 locations
Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders

This phase II trial studies the effect of fecal microbiota transplant and re-introduction of anti-PD-1 therapy (pembrolizumab or nivolumab) in treating anti-PD-1 non-responders with colorectal cancer that has spread to other places in the body (metastatic). Fecal microbiota transplants contain the normal bacteria and viruses found in fecal (stool) material. …

  • 0 views
  • 12 Aug, 2021
  • 1 location
Phase II Trial of Fruquintinib With Sintilimab in Treating Selected Refractory Metastatic Colorectal Cancer Patients

This is a prospective, Single arm Phase II trial. Patients were eligible to participate when they had histological or cytological confirmed metastatic colorectal adenocarcinoma Non-MSI

  • 0 views
  • 28 Jan, 2021
  • 1 location
Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer

This phase II clinical trial studies how well panitumumab with or without trametinib works in treating patients with stage IV colorectal cancer. Immunotherapy with monoclonal antibodies, such as panitumumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and …

  • 20 views
  • 23 Jan, 2021
  • 2 locations