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Found 27 clinical trials
Imaging With [89Zr]Panitumumab-PET/MRI in Patients With Newly Diagnosed Colorectal Cancer

This clinical study will investigate the utility of PET imaging with [89Zr]Panitumumab for imaging of EGFR expression in newly diagnosed colon cancer patients to assess lymph node involvement. If promising, this data will be used to design larger trials.

EGFR
cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients

The aim of this study is to prospectively determine the incidence of brain metastases in metastatic colorectal cancer patients using systematic annual screening by MRI.

cancer
metastatic colorectal cancer
brain metastases
metastasis
adenocarcinoma
  • 0 views
  • 26 Jan, 2021
  • 1 location
Development of Clinical and Biological Database in Colorectal Cancer

Creation of circulating cancer cell-lines and caracterisation of these cell-lines which will be collected before any treatment in patients with metastatic colon adenocarcinoma

adenocarcinoma
cancer
metastatic colorectal cancer
  • 1 views
  • 26 Jan, 2021
  • 1 location
The Value of Palliative Primary Tumor Resection in Metastatic Colon Cancer

The aim of this trial is to evaluate the value of palliative primary tumor resection in colon cancer patients with initially unresectable metastases and a positive response to induction chemotherapy which depends on gene testing. The primary endpoint is to evaluate overall survival.

cancer
systemic chemotherapy
metastasis
adenocarcinoma of colon
adenocarcinoma
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Study of Efficacy and Safety of Fruquintinib (HMPL-013) in Patients With Metastatic Colorectal Cancer

This is a global, randomized, double-blind, placebo-controlled, multicenter phase 3 clinical trial to compare the efficacy and safety of fruquintinib plus best supportive care (BSC) versus placebo plus BSC in patients with refractory metastatic colorectal cancer (mCRC). 687 subjects will be randomized to one of the following treatment arms in …

fruquintinib
adjuvant therapy
oxaliplatin
regorafenib
cancer
  • 0 views
  • 30 Apr, 2021
  • 139 locations
Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer

This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). 'Metastatic' means that the cancer has spread to other parts of the body. In the first part of this study, …

bevacizumab
monoclonal antibodies
HER2
irinotecan
adenocarcinoma
  • 308 views
  • 06 Jun, 2021
  • 80 locations
TAS-102 and Oxaliplatin for the Treatment of Refractory Stage IV Colon Cancer

This phase II trial studies how well TAS-102 and oxaliplatin work in treating patients with stage IV colon cancer. Drugs used in chemotherapy, such as TAS-102 and oxaliplatin, work in different

bevacizumab
tas-102
irinotecan
absolute neutrophil count
neutrophil count
  • 0 views
  • 01 Mar, 2021
  • 2 locations
Palbociclib and Cetuximab in Metastatic Colorectal Cancer

This research study is designed to provide a better understanding of study drugs cetuximab (Erbitux) and palbociclib when used in combination to treat patients with metastatic colon cancer.

colon cancer
liver metastasis
KRAS
adjuvant chemotherapy
oxaliplatin
  • 343 views
  • 25 Jan, 2021
  • 1 location
Autologous Killer Cell Therapy in Colon Cancer Patients

This study aims to evaluate the safety and efficacy of activated and expanded autologous cytokine-killer cells in controlling disease recurrence in colon cancer patients with liver metastasis. 20 patients with confirmed stage IV colon carcinoma with metastasis will be assigned into two groups. Patients in both groups will receive the …

  • 0 views
  • 21 Mar, 2021
  • 1 location
A Study of Bevacizumab Infusional Fluorouracil Leucovorin Oxaliplatin and Irinotecan (A-FOLFOXIRI) Compared With Bevacizumab Infusional Fluorouracil Leucovorin and Irinotecan/Oxaliplatin (A-FOLFIRI/FOLFOX) as First-line Treatment for Metastatic Right-sided Colon Cancer

RATIONALE: Recently, the importance of prognosis according to the location of the primary tumor in colorectal cancer has been raised. In the CALGB / SWOG 80405 study published in 2016, the addition of bevacizumab or cetuximab to the first line FOLFIRI / FOLFOX in KRAS (codon 12, 13) wild type …

  • 0 views
  • 25 Jan, 2021
  • 1 location