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Found 15 clinical trials
Immune Checkpoint Inhibitor and MR-guided SBRT for Limited Progressive Metastatic Carcinoma.

This is an open label single arm phase 2 clinical trial in patients with metastatic solid malignancy of any histology who have previously experienced limited progression in at least 1 and up to 5 lesions while on immune checkpoint inhibitors monotherapy.

  • 11 Apr, 2021
  • 1 location
Platinum Chemotherapy Plus Paclitaxel With Bevacizumab and Atezolizumab in Metastatic Carcinoma of the Cervix

The study will integrate the efficacy of combining the anti programmed death-ligand 1 (anti-PD-L1) agent atezolizumab with the current standard of care in Stage IVB , persistent or recurrent carcinoma of the cervix, namely cisplatin or carboplatin/paclitaxel/bevacizumab. It will be explored the combination of bevacizumab plus atezolizumab, with no patient …

  • 26 Jan, 2021
  • 91 locations
Anti-HER2 Therapy in Patients of HER2 Positive Metastatic Carcinoma of Digestive System

To seek the efficacy signals of trastuzumab in combination with chemotherapy in pretreated patients of HER2 positive, relapse or metastatic carcinoma of digestive system as response rate (RR

measurable disease
liver metastasis
systemic therapy
  • 22 Jan, 2021
  • 1 location
Study of Niraparib With Radiotherapy for Treatment of Metastatic Invasive Carcinoma of the Cervix

The most effective strategy for managing distantly metastatic invasive carcinomas of the cervix is not defined. Based on the success of niraparib in breast and ovarian cancer trials and the concern for toxicities and comorbidities limiting the compliance of concurrent cisplatin for cervical cancer, this study is a phase I/II …

  • 18 Feb, 2021
  • 3 locations
Temozolomide in Preventing Brain Metastases in Small Cell Lung Cancer

To investigate the response of temozolomide versus prophylactic cranial radiotherapy in preventing brain metastases in completed or partial remission limited small cell lung cancer patients.

  • 23 Jan, 2021
  • 1 location
BMS-986156 Ipilimumab and Nivolumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Lung/Chest or Liver Cancers

This phase I/II trial studies the side effects and best dose of anti-glucocorticoid-induced tumor necrosis factor receptor (GITR) agonistic monoclonal antibody BMS-986156 (BMS-986156) when given together with ipilimumab and nivolumab with or without stereotactic body radiation therapy and to see how well they work in treating patients with lung/chest or …

growth factor
liver cancer
blood transfusion
  • 01 Feb, 2021
  • 1 location
INTERVAL - Intense Exercise Trial for Men With Metastatic Castrate-Resistant Prostate Cancer

Exercise has been established to be safe and result in improved physical function and quality of life for most individuals with cancer. However, little information exists regarding whether exercise can increase overall survival and reduce disease progression, events related to cancer spreading to the bones (e.g. bone fracture, spinal cord …

bilateral orchidectomy
bone scan
  • 25 Jan, 2021
  • 4 locations
Combined Deep Inspiration Breath Hold (DIBH)-Expiration Planning Technique in Patients With Lung Tumors in Close Proximity to the Chest Wall

The purpose of this study is to evaluate a new radiation planning and treatment delivery technique called Deep Inspiration Breath Hold (DIBH) and expiration technique. This technique will be used to treat patients who have tumors close to the chest wall and are candidates for Stereotactic Body Radiation Therapy (SBRT). …

karnofsky performance status
lung tumor
lung carcinoma
  • 26 Jan, 2021
  • 1 location
Treatment Of Metastatic Bladder Cancer at the Time Of Biochemical reLApse Following Radical Cystectomy

Immunotherapy (checkpoint inhibitors) is approved as first and second line treatment to patients with metastatic bladder cancer. However, response rates are low and no biomarkers have yet shown strong predictive value for patient selection. Moreover, the term 'metastatic' is based on metastases visible on conventional CT scans and, thus, require …

radical cystectomy
metastatic bladder carcinoma
bladder tumor
  • 27 Mar, 2021
  • 5 locations
Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

This study will examine the combination of pembrolizumab and tadalafil for safety and efficacy in advanced head and neck cancer.

measurable disease
head and neck cancer
metastatic squamous cell carcinoma
neck cancer
  • 24 Jan, 2021
  • 1 location