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Found 7 clinical trials
First-line Gemcitabine/Cisplatin +/- Avelumab in Locally Advanced or Metastatic Bladder Carcinoma

This study will assess efficacy (based on response rate) and safety (based on grade 3 severe adverse effects) of the combination Gemcitabine Cisplatin (GC) + anti-PD-L1 (avelumab) in first-line treatment for locally advanced or metastatic urothelial bladder cancer patients, after 6 cycles of treatment (or at 18 weeks if less …

metastatic bladder carcinoma
cisplatin/gemcitabine
carcinoma
bladder tumor
bladder carcinoma
  • 20 views
  • 26 Jan, 2021
  • 20 locations
Chidamide With Immunotherapy for Patients With Locally Advanced or Metastatic Urothelial Carcinoma

Study of Chidamide Combined With Immunotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Who Had Previously Received Platinum-based Chemotherapy

  • 0 views
  • 26 Jan, 2021
  • 1 location
Trilaciclib a CDK 4/6 Inhibitor in Patients With Advanced/Metastatic Bladder Cancer Receiving Chemotherapy Then Avelumab

This is a Phase 2, multicenter, randomized, open-label study evaluating the safety and efficacy of trilaciclib administered with platinum-based chemotherapy followed by trilaciclib administered with avelumab maintenance therapy compared with platinum-based chemotherapy followed by avelumab maintenance therapy in patients receiving first-line treatment for advanced/metastatic bladder cancer.

bladder cancer
carboplatin
bladder tumor
cancer
avelumab
  • 0 views
  • 16 Jul, 2021
  • 1 location
Afatinib in Advanced Refractory Urothelial Cancer

This phase II trial studies how well afatinib dimaleate works in treating patients with urothelial cancer that cannot be removed surgically and has grown after treatment with standard first-line chemotherapy. Afatinib dimaleate may turn off the function of the epidermal growth factor (EGF) and human epidermal growth factor receptor 2 …

human epidermal growth factor receptor 2
absolute neutrophil count
carcinoma
systemic chemotherapy
spiral computed tomography
  • 29 views
  • 26 Jan, 2021
  • 4 locations
A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

This study will be conducted in adult subjects diagnosed with any form of an advanced or metastatic solid tumors including urothelial carcinoma for which standard therapy is no longer effective or is intolerable. This is a phase 1, multi-center, open label study designed to assess safety and tolerability of IK-175 …

biological factors
nitrosoureas
treatment regimen
solid neoplasm
carcinoma
  • 8 views
  • 28 Mar, 2021
  • 6 locations
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that have spread to other places in the body. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. …

monoclonal antibodies
cabozantinib
hormone therapy
programmed cell death 1 ligand 1
carcinoma
  • 191 views
  • 25 Jul, 2021
  • 474 locations
Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer

This study collects and studies tissue and blood samples from patients with prostate or bladder/urothelial cancer that has recurred (come back) at or near the same place as the original (primary) tumor or has spread to other parts of the body. Studying samples of blood and tissue samples from patients …

cancer
bone metastases
metastasis
platelet count
transurethral resection
  • 97 views
  • 20 Jun, 2021
  • 1 location