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Found 9 clinical trials
A Study of MRG002 in the Treatment of HER2-positive Unresectable, Locally Advanced or Metastatic Biliary Tract Cancer

The objective of this study is to assess the safety, efficacy, pharmacokinetics, and immunogenicity of MRG002 as single agent in HER2-positive unresectable locally advanced or metastatic biliary

  • 0 views
  • 18 Dec, 2021
  • 7 locations
Pembrolizumab in Combination With Lenvatinib in Patients With Advanced Cholangiocarcinoma

The prognosis for unresectable and metastatic biliary tract cancers (BTCs) including cholangiocarcinoma is poor with first line gemcitabine and cisplatin offering a median overall survival of

  • 0 views
  • 26 Aug, 2021
  • 2 locations
A Study of RC48-ADC in Subjects With HER2 Overexpressed Metastatic Biliary Tract Cancer

This study will evaluate the efficacy and safety of intravenous RC48-ADC in patients with locally advanced or metastatic HER2 overexpressed biliary tract cancer who have failed first-line chemotherapy.

fluorouracil
gemcitabine
measurable disease
cholangiocarcinoma
gallbladder cancer
  • 4 views
  • 03 Mar, 2022
  • 16 locations
Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

This phase II trial studies how well olaparib works in treating patients with biliary tract cancer that has spread to other places in the body (metastatic) and with aberrant DNA repair gene mutations. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

cancer
platelet count
olaparib
measurable disease
hysterectomy
  • 0 views
  • 29 May, 2022
  • 5 locations
Rucaparib in Combination With Nivolumab in Patients With Advanced or Metastatic Biliary Tract Cancer Following Platinum Therapy

Investigators hypothesize that following first-line platinum based chemotherapy, rucaparib in combination with nivolumab, will improve progression-free survival and overall survival in BTC patients.

ffpe
adenocarcinoma
measurable disease
gall bladder
rucaparib
  • 10 views
  • 22 Mar, 2022
  • 2 locations
TST001 in Patients With CLDN18.2 Positive Previously Treated Advanced Biliary Tract Cancer

patients with CLDN18.2 positive previously treated unresectable advanced or metastatic Biliary Tract Cancer.

  • 0 views
  • 17 Jun, 2022
  • 1 location
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers

Lymphocytes (TIL) and high-dose aldesleukin in patients with locally advanced, recurrent, or metastatic biliary tract cancer. These are low-incidence cancers carry a poor prognosis. Participants will include

platelet count
cancer
cholangiocarcinoma
gallbladder cancer
systemic therapy
  • 28 views
  • 04 Jun, 2022
Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer

This phase I/II trial studies the side effects and best dose of liposomal irinotecan and rucaparib when given together with fluorouracil and leucovorin calcium and to see how well they work in treating patients with pancreatic, colorectal, gastroesophageal, or biliary cancer that has spread to other places in the body …

platelet count
cancer
measurable disease
tumor cells
metastatic adenocarcinoma
  • 8 views
  • 16 Jun, 2022
  • 3 locations
Trial of Infusional FOLFIRINOX in First Line Treatment of Advanced Biliary Tract Cancers (FBI-TRAC)

This study is to evaluate the response rate and toxicity profile of infusional 5 fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFIRINOX) in first-line treatment of advanced biliary tract cancers and also to assess progression free survival and overall survival of FOLFIRINOX in first line treatment of advanced biliary tract cancers

fluorouracil
platelet count
measurable disease
biliary cancer
oxaliplatin
  • 5 views
  • 25 Feb, 2022
  • 1 location