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Found 8887 clinical trials
Featured trial
Preventing Alzheimer's With Cognitive Training (PACT)

Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and …

cognitive stimulation
Accepts healthy volunteers
mild cognitive impairment
dementia
cognitive impairment
  • 1 views
  • 28 Oct, 2022
  • 5 locations
Featured trial
Phase 2, Open-Label, Multicenter Study of INCAGN01876 in Combination With Immunotherapy in Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

The purpose of this study is to determine the safety, tolerability, efficacy, PK and pharmacodynamics of INCAGN01876 when given in combination with retifanlimab. The study will consist of 2 parts: a safety lead-in part (Part 1) followed by a dose expansion part (Part 2).

carcinoma
measurable disease
  • 0 views
  • 28 Oct, 2022
  • 2 locations
Featured trial
SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patients (CARMEN-LC03)  

intensity in at least 50% of the tumor cell population and previously treated with standard-of-care platinum-based chemotherapy and an immune checkpoint inhibitor. Secondary Objectives:

  • 180 views
  • 27 Jan, 2023
  • 5 locations
Featured trial
Dupilumab in CRSsNP (Liberty CRSsNP ORION)  

total symptom score (sTSS) compared to placebo Secondary Objectives: Part A To evaluate the efficacy of dupilumab as assessed by the reduction at Week 52 in sinus

asthma
obstruction
congestion
rhinorrhea
ct scan
  • 20 views
  • 27 Jan, 2023
  • 8 locations
Featured trial
Study in Parkinson Disease of Exercise (SPARX3)

This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax …

SPECT Scan
movement disorder
datscan
  • 169 views
  • 07 Oct, 2022
  • 26 locations
Featured trial
Arcadia: AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke

cardiopathy. Secondary: To test the hypothesis that the relative efficacy of apixaban over aspirin increases with the severity of atrial cardiopathy.

  • 0 views
  • 29 Nov, 2022
  • 1 location
Featured trial
GOG 3043: A Randomized Controlled Trial of Robotic versus Open Radical Hysterectomy for Cervical Cancer (ROCC trial)

The purpose of this study is to investigate if minimally invasive surgery, called robotic assisted laparoscopy (small incision surgery), is worse than open surgery (otherwise known as a laparotomy) when performing a radical hysterectomy for cervical cancer. A radical hysterectomy is surgery to remove the uterus, cervix, the parametria (tissue …

  • 0 views
  • 26 Aug, 2022
  • 1 location
Featured trial
Pilot Study of Topical Dexamethasone 0.01% Solution for Prevention of Oral Chronic Graft Versus Host Disease

This study will determine if a dexamethasone mouth rinse can reduce the risk of developing oral chronic graft-versus-host disease (cGVHD) in patients who have undergone a bone marrow (stem cell) transplant procedure. cGVHD is a common complication of stem cell transplantation, resulting from the donor cells attacking the transplant recipient's …

graft versus host disease
graft-versus-host disease
  • 164 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) Patients that are Treatment Naive or Receiving Bruton s-Tyrosine Kinase Inhibitor (BTK-I) Therapy

Background: People who have cancer tend to get sick more often. This is in part because of the cancer treatments they get. Because of this, they may get shingles. Scientists had thought people with chronic lymphocytic leukemia (CLL) should not get the shingles vaccine. Now there is a new shingles …

acalabrutinib
ibrutinib
cancer
lymphoma
chronic lymphocytic leukemia
  • 238 views
  • 09 Apr, 2019
  • 1 location
Featured trial
Response to the HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) Patients that are Treatment Naive or Receiving Bruton s-tyrosine Kinase Inhibitor (BTK-I) Therapy

Background: People with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) tend to get infections more easily. This is because their immune systems are weakened. Hepatitis B is a virus that can be transmitted when body fluids from an infected person enter the body of an uninfected person. This …

acalabrutinib
ibrutinib
lymphoma
chronic lymphocytic leukemia
  • 67 views
  • 09 Apr, 2019
  • 1 location