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Found 10113 clinical trials
Featured trial
A Phase 1, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral TP-3654 in Patients with Intermediate or High-Risk Primary or Secondary Myelofibrosis

This is a Phase 1, multicenter, dose-escalation, open-label study to assess safety, tolerability, preliminary activity, pharmacokinetics and pharmacodynamics of TP-3654 in patients with intermediate-2 or high-risk myelofibrosis.

  • 26 views
  • 31 May, 2022
  • 5 locations
Featured trial
  • 0 views
  • 26 Aug, 2022
  • 1 location
Featured trial
A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients With Advanced Solid Tumors With KRAS G12C Mutation

Evaluates the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 is an orally-available small molecule inhibitor of KRAS G12C.

malignant solid tumor
solid tumor
advanced solid tumor
  • 538 views
  • 22 Nov, 2021
  • 62 locations
Featured trial
A Phase 1/2 Trial of MRTX849 in Combination with TNO155 in Patients with Advanced Solid Tumors with KRAS G12C Mutation

Characterize the safety and tolerability, and evaluate Pharmacokinetics of MRTX849 in combination with TNO155 in patients with advanced solid tumor malignancies with KRAS G12C mutation. MRTX849 is an orally available small molecute inhibitor of KRASG12C. TNO155 is a selective, orally bioavailable allosteric inhibitor of wild type SHP2.

solid tumors
solid tumor
advanced solid tumor
malignant solid tumor
  • 179 views
  • 19 Feb, 2021
  • 4 locations
Featured trial
  • 690 views
  • 08 Nov, 2020
  • 1 location
Featured trial
Memory Loss Prevention

prevention for those at risk of developing dementia secondary to Alzheimer’s disease even before symptoms occur.Research studies for “memory loss prevention” include those who are at

alzheimer's disease
dementia
  • 29 views
  • 30 Jul, 2021
  • 1 location
Featured trial
Prostate Cancer

Prostate Cancer

  • 76 views
  • 08 Nov, 2020
  • 1 location
Featured trial
Pacific 4: A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab with Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients with unresected Stage I/II, lymph-node negative Non-small Cell Lung Cancer (PACIFIC-4/RTOG-3515)

This is a Phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab with SoC SBRT versus placebo with SoC SBRT in patients with unresected clinical Stage I/II lymph node-negative (T1 to T3N0M0) NSCLC.

  • 0 views
  • 26 Aug, 2022
  • 1 location
Featured trial
PLUS 1 Study

PLUS 1 Study

  • 249 views
  • 08 Nov, 2020
  • 1 location
Featured trial
Enlarged Prostate

Enlarged Prostate

  • 56 views
  • 08 Nov, 2020
  • 1 location