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Found 95 clinical trials
Tagraxofusp (SL-401) in Patients With CMML or MF

This multi-center, multi-arm trial is evaluating the safety and efficacy of tagraxofusp, a CD123-targeted therapy, in patients with either chronic myelomonocytic leukemia (CMML) or myelofibrosis (MF). There are two CMML cohorts, one enrolling patients with CMML (CMML-1 or CMML-2) who are refractory/resistant or intolerant to hypomethylating agents (HMA), hydroxyurea (HU), …

chronic myelomonocytic leukemia
platelet count
leukemia
cmml-2
anemia
  • 145 views
  • 10 May, 2022
  • 10 locations
Study of DISC-0974 in Participants With Myelofibrosis and Anemia

This phase 1b/2a open-label study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of DISC-0974 as well as categorize the effects on anemia response in subjects with myelofibrosis and anemia.

platelet count
erythropoietin
anemia
serum ferritin level
lenalidomide
  • 0 views
  • 01 Jul, 2022
  • 2 locations
Study of Tagraxofusp for Post-Transplant Maintenance for Patients With CD 123+ AML, MF and CMML (HSCT 002)

In this study, tagraxofusp (Tag) is given to patients with CD 123+ myelofibrosis (MF), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML) after allogeneic stem cell transplant (HCT) to help prevent relapse. Patients will receive up to about 9 cycles of treatment with Tag and have a bone marrow …

cancer
chronic myelomonocytic leukemia
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Study of LNK01002 in Patients With Primary (PMF) or Secondary Myelofibrosis (PV-MF ET-MF) or Acute Myeloid Leukemia

This multicenter, open-label, phase 1 study designed to evaluate safety and tolerability of multi-kinase inhibitor LNK01002 in patients with primary myelofibrosis (MF), or MF due to polycythemia vera (PV-MF), or essential thrombocythemia (ET-MF), or with acute myeloid leukemia (AML).

refractory acute myeloid leukemia (aml)
  • 0 views
  • 17 Jun, 2021
  • 3 locations
Ruxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myeloproliferative Neoplasm

This phase II trial studies how well ruxolitinib phosphate and azacytidine work in treating patients with myelofibrosis or myelodysplastic syndrome/myeloproliferative neoplasm. Ruxolitinib phosphate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as azacytidine, work in different …

myelodysplastic/myeloproliferative neoplasms
myeloproliferative neoplasm
myeloproliferative disorder
thrombocytosis
azacitidine
  • 226 views
  • 04 Oct, 2022
  • 1 location
Testing the Effect of Taking Ruxolitinib and CPX-351 in Combination for the Treatment of Advanced Phase Myeloproliferative Neoplasms

This phase I/II trial studies the best dose of ruxolitinib when given together with CPX-351 and to see how well they work in treating patients with accelerated phase or blast phase myeloproliferative neoplasm. Ruxolitinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell …

jak2 inhibitor
daunorubicin
induction chemotherapy
bone marrow procedure
potassium
  • 13 views
  • 06 Jun, 2022
  • 1 location
Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy

epithelium in vivo and histological diagnosis during endoscopy. Among the applications already established for its use, stand out diagnosis of Barrett's esophagus, gastric atrophy and intestinal metaplasia

endoscopy
gastric cancer
confocal laser endomicroscopy
carcinoma
metaplasia
  • 14 views
  • 12 Feb, 2022
  • 1 location
Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms

The purpose of this research study is to test the safety of a new three drug combination of navitoclax, decitabine, and venetoclax to treat advanced myeloid malignancies. The names of the drugs involved in this study are: Venetoclax Decitabine Navitoclax

venetoclax
gilbert's syndrome
decitabine
myelofibrosis
blast cells
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT

In this research study, our main goal for the ipilimumab portion of the study is to determine the highest dose of ipilimumab that can be given safely in several courses and to determine what side effects are seen in patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), Myeloproliferative Neoplasms …

chronic myelomonocytic leukemia
bone marrow procedure
hemolysis
myelodysplastic/myeloproliferative neoplasm
myelodysplastic/myeloproliferative neoplasms
  • 346 views
  • 03 Jul, 2022
  • 2 locations
Decitabine With Ruxolitinib or Fedratinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

This phase II trial studies how well decitabine with ruxolitinib or fedratinib works before hematopoietic stem cell transplant in treating patients with accelerated/blast phase myeloproliferative neoplasms (tumors). Drugs used in chemotherapy, such as decitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, …

blood cell counts
white blood cell count
myeloid leukemia
leukapheresis
thrombocytosis
  • 14 views
  • 04 Oct, 2022
  • 1 location