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Found 76 clinical trials
Hypofractionated Radiation Therapy for Merkel Cell Carcinoma

This study seeks to determine the safety and efficacy of shortening the primary and nodal adjuvant radiation therapy course from 2 Gy x 25 fractions to 3.6 Gy x 10 fractions in merkel cell

immunomodulator
tubal ligation
hysterectomy
metastasis
  • 0 views
  • 22 Mar, 2022
  • 1 location
Neoadjuvant Lenvatinib Plus Pembrolizumab in Merkel Cell Carcinoma

This is a single arm trial of participants with Merkel cell carcinoma receiving a combination of lenvatinib plus pembrolizumab.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Study To Evaluate The Safety, Tolerability And Immunogenicity Of 4 mg Of ITI-3000 In Patients With Polyomavirus-Positive Merkel Cell Carcinoma (MCC)

This Phase I clinical trial will evaluate the safety, tolerability, and immunogenicity of 4 mg doses of ITI-3000 in participants with polyomavirus-positive Merkel cell carcinoma (MCC).

neutrophil count
platelet count
renal function
  • 0 views
  • 04 Oct, 2022
  • 1 location
Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell Carcinoma (I-MAT)

The I-MAT trial is a randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma aiming to explore the efficacy of avelumab as adjuvant

ct scan
immunomodulator
metastasis
carcinoma
positron emission tomography
  • 6 views
  • 07 Oct, 2022
  • 17 locations
Neoadjuvant Cemiplimab in Stage I-II Merkel Cell Carcinoma: Safety and Biomarker Analysis

Cell Carcinoma.

neutrophil count
platelet count
renal function
  • 0 views
  • 08 Jun, 2022
  • 1 location
A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors

This phase II trial studies how well talimogene laherparepvec and nivolumab work in treating patients with lymphomas that do not responded to treatment (refractory) or non-melanoma skin cancers that have spread to other places in the body (advanced) or do not responded to treatment. Biological therapies, such as talimogene laherparepvec, …

trichilemmal carcinoma
squamous cell carcinoma
mycosis fungoides
intralesional injection
measurable disease
  • 511 views
  • 10 Oct, 2022
  • 6 locations
A Phase II Single-Arm Clinical Trial Assessing Comprehensive Ablative Radiation Therapy With Avelumab in Unresectable and Metastatic Merkel Cell Carcinoma (CARTA)

This study will test the use of comprehensive ablative radiation therapy (CART), with the immunotherapy drug avelumab, in people with Merkel cell carcinoma (MCC) that has progressed after

neutrophil count
platelet count
  • 0 views
  • 18 Oct, 2022
  • 7 locations
A Phase 1b/2a, Open Label Study to Evaluate Anti-tumor Efficacy and Safety of rhIL-7-hyFc (NT-I7) in Combination With Anti-PD-L1 (Atezolizumab) in Patients With Anti-PD-1/PD-L1 naïve or Relapsed/Refractory High-risk Skin Cancers

-risk melanoma, Merkel Cell Carcinoma (MCC) and cutaneous Squamous Cell Carcinoma (cSCC)

skin cancer
mek inhibitor
atezolizumab
squamous cell carcinoma
pd-l1
  • 14 views
  • 10 Oct, 2022
  • 7 locations
STAMP: Surgically Treated Adjuvant Merkel Cell Carcinoma With Pembrolizumab, a Phase III Trial

This phase III trial studies how well pembrolizumab works compared to standard of care observation in treating patients with stage I-III Merkel cell cancer that has been completely removed by

  • 22 views
  • 22 Oct, 2022
  • 403 locations
Gene-Modified Immune Cells (FH-MCVA2TCR) in Treating Patients With Metastatic or Unresectable Merkel Cell Cancer

This phase I/II trial studies the side effects of gene-modified immune cells (FH-MCVA2TCR) and to see how well they work in treating patients with Merkel cell cancer that has spread to other

  • 0 views
  • 03 Jun, 2022
  • 1 location