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Found 36 clinical trials
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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis

  • 248 views
  • 23 Nov, 2020
  • 1 location
Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more …

cancer
thioguanine
methotrexate
cyclophosphamide
cytarabine
  • 1 views
  • 07 Nov, 2020
  • 5 locations
Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. A donor stem cell transplant may replace the patient's immune cells …

cancer
thioguanine
methotrexate
graft-versus-tumor
cyclophosphamide
  • 0 views
  • 07 Nov, 2020
  • 1 location
AIDA2000 - Risk-Adapted Therapy for Patients With Acute Promyelocytic Leukemia

. Finally a two year period of maintenance therapy with 6-mercaptopurine, methotrexate and ATRA is performed.

methotrexate
retinoids
tretinoin
consolidation therapy
maintenance therapy
  • 40 views
  • 07 Nov, 2020
  • 1 location
Venetoclax SL-401 and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm

This phase II trial studies how well venetoclax, SL-401, and chemotherapy works in treating patients with blastic plasmacytoid dendritic cell neoplasm. Venetoclax may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. SL-401 is a recombinant protein consisting of IL-3 linked to a …

  • 0 views
  • 19 Jan, 2021
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

. Drugs used in chemotherapy, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in

leucovorin
cancer
methotrexate
blinatumomab
white blood cell count
  • 84 views
  • 18 Jan, 2021
  • 117 locations
Ileal Crohn's Disease and Post-operative Outcome: Prospective Cohort Study of the REMIND Group

-operative recurrence : Thiopurines, 6-mercaptopurine (positive for clinical and endoscopic postoperative recurrence prevention), Anti-tumour necrosis factor therapy (anti-TNF), the most effective therapy

thiopurines
crohn's disease
bowel resection
microbiota
tumour necrosis
  • 9 views
  • 11 Nov, 2020
  • 17 locations
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL Mixed Phenotype Acute Leukemia and B-LLy

. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine

leucovorin
cancer
methotrexate
cancer chemotherapy
white blood cell count
  • 42 views
  • 01 Jan, 2021
  • 109 locations
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

predictors of treatment outcome. To perform a detailed assessment of thiopurine metabolism and 6-mercaptopurine (6MP) tolerance, toxicity, and treatment outcome. To establish xenografts

cancer
methotrexate
remission
blinatumomab
flow cytometry
  • 230 views
  • 17 Jan, 2021
  • 6 locations
Dose-Ranging Phase 2b Study of ABX464 in Moderate to Severe Ulcerative Colitis

Phase IIb study to evaluate the efficacy and the safety of 3 dose-levels of ABX464, administered daily in patients with moderate to severe Ulcerative Colitis.

vedolizumab
methotrexate
loperamide
tumour necrosis
janus kinase inhibitor
  • 132 views
  • 24 Jan, 2021
  • 163 locations