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Found 1328 clinical trials
The GBA Multimodal Study in Parkinson's Disease

This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and …

  • 16 Apr, 2021
  • 3 locations
Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)

Background A radioligand is a radioactive substance that is used to diagnose diseases. A new ligand is called [11C]PS13. This has a small amount of radioactivity that can be detected by a positron emission tomography (PET) scan. If this ligand works well in this study, researchers may be able to …

  • 15 Sep, 2021
  • 1 location
Evaluation of the Links Between Sleep Disorders and the Risk of Suicide Attempt

Several studies have demonstrated an association between sleep disorders such as insomnia and nightmares to suicidal ideations and behaviors. Nevertheless, some of these studies are methodologically questionable especially in the exploration of sleep disorders. Furthermore, confounding factors such as depressive symptomatology are not controlled and the measurement of suicidal behavior …

  • 25 Jan, 2021
Surgically Induced Neurological Deficits in Glioblastomas (SIND Study)

This study provides a work package for a larger programme of research developing Precision Surgery for Glioblastomas by developing individualised treatment volumes for surgery and radiotherapy. This study will recruit a cohort of patients with tumours in different brain regions and involve imaging pre- and post-operatively to outline the area …

tumour resection
  • 30 Jul, 2021
  • 1 location
Quantifying Digital Behavior on Smart Phones - Data From Stroke Survivors

In this study, we want to continuously record the interaction of 50 stroke survivors with their smartphones during the first 3 months after discharge. The linkage of smart phone use to function and quality of life will be assessed with standardized outcome measures at defined time points.

recurrent strokes
  • 05 May, 2021
  • 1 location
Bioenergetic Profiling and Cognition in GBM Patients

This trial studies the use of blood-based bioenergetic profiling and cognitive testing in assessing patients with glioblastoma undergoing chemoradiation therapy. The purpose of this pilot research study is to find out if it is possible to see changes in participants' mitochondria, parts of a cell that produce energy, that might …

karnofsky performance status
malignant glioma
  • 05 Jul, 2021
  • 1 location
Florbetaben PET Imaging in PPA

The purpose of this research is to better understand how dementia affects activity in different parts of the brain.

  • 29 Apr, 2021
  • 1 location
Correlation Between Non-motor Symptoms and Malnutrition in Patients With Parkinson's Disease

This study used Mini Nutrition Assessment (MNA) , Nutrition risk screening 2002(NRS-2002) and Non-motor Symptom Quest (NMSquest) to investigate the nutritional status of patients with Parkinson's disease, to analyze the correlation between non-motor symptoms and malnutrition in patients with Parkinson's disease (PD) , and to provide evidence for clinical treatment …

motor symptoms
  • 27 Jun, 2021
  • 1 location
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study

Carotid artery disease is a main cause of ischemic stroke and vascular dementia, and a highly prevalent disease. There is uncertainty about the optimal management of patients with serendipitously or systematically detected asymptomatic carotid artery disease, due to the paucity of information on the predictive features of serious vascular events. …

  • 27 Jan, 2021
  • 1 location
Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

This research study is designed to look at the involvement of the glutamate system and synaptic density in depression and bipolar disorder. Each participant will undergo a screening appointment to determine study eligibility. Thereafter, the study will take 2 or 3 visits depending on schedule availability and will consist of …

depressive disorder
psychiatric disorder
depressed mood
bipolar disorder
  • 06 Mar, 2021
  • 1 location