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Found 1328 clinical trials
Childhood Outcomes of Preterm Brain Abnormalities

Prematurely born children are at higher risk of cognitive impairments and behavioral disorders than full-term children. There is growing evidence of significant volumetric and shape

brain injury
neuropsychological assessment
prematurity
Accepts healthy volunteers
  • 51 views
  • 28 Jun, 2022
  • 1 location
ROSE-Longitudinal Assessment With Neuroimaging

The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline …

  • 0 views
  • 28 Oct, 2021
  • 7 locations
F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (DIAN Project) (AV ADAD)

The purpose of this research study is to evaluate a new radioactive compound used in positron emission tomography (PET) scans in identifying tau tangles (a certain protein that might be associated with Dominantly Inherited Alzheimer's Disease) in the brain, and if the amount of tau tangles in the brain has …

dementia
positron emission tomography
mild dementia
alzheimer's disease
  • 5 views
  • 24 Jan, 2022
  • 1 location
PhosphoRus, Proton Imaging and Amyloid BuRdEn (PREPARE) ON AMYLOID BURDEN AND COGNITION (PREPARE)

Normal cells primarily produce energy with the help of the "mitochondria". These "small organs" are also called the "powerhouses of the cell" turn the sugars, fats and proteins that is eaten into forms of chemical energy that the body can use to carry on living. This process is called oxidative …

amyloidosis
dementia
amyloid
mental state examination
mini-mental state examination
  • 3 views
  • 09 Aug, 2022
  • 1 location
Long Term Outcomes of Patients With COVID-19 (COVID19 LTFU)

The investigators hypothesize that those with respiratory failure due to COVID-19 will have different burdens of mental and physical disability than those with respiratory failure who do not have COVID-19. Detecting these potential differences will lay an important foundation for treating long term sequelae of respiratory failure in these two …

respiratory failure
covid-19
  • 50 views
  • 05 Mar, 2022
  • 1 location
Imaging a Cholinergic Biomarker of Cognition in Parkinson's Disease

This is an imaging study designed to illuminate the function of the cholinergic system and its association with cognitive skills in people with Parkinson's disease. The hypothesis of this study is that there will be an association between cholinergic terminal density, sex hormones, and cognitive functioning. Participants will receive a …

cognitive impairment
  • 0 views
  • 25 Jan, 2022
  • 1 location
The GBA Multimodal Study in Parkinson's Disease

This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and …

gba gene
acetylcholine
dopamine
positron emission tomography
parkinson's disease
  • 0 views
  • 25 Jan, 2022
  • 3 locations
Evaluation of the Links Between Sleep Disorders and the Risk of Suicide Attempt (HYPNOS)

Several studies have demonstrated an association between sleep disorders such as insomnia and nightmares to suicidal ideations and behaviors. Nevertheless, some of these studies are methodologically questionable especially in the exploration of sleep disorders. Furthermore, confounding factors such as depressive symptomatology are not controlled and the measurement of suicidal behavior …

insomnia
suicidal
  • 3 views
  • 12 Feb, 2022
Tracking of Upper Limb Sensory and Motor Recovery in Asian Stroke Survivors

As Singapore's population is aging rapidly, the incidence rate of stroke has been increasing in the past years. Rehabilitation is essential for the resumption of daily activities, and with the appropriate care, it is possible for stroke-survivors to regain most of their functions. Hence, this study aims to better understand …

  • 0 views
  • 27 Apr, 2022
  • 1 location
Long-term Impact in Intensive Care Survivors of Coronavirus Disease-19 (AFTERCOR) (AFTERCOR)

The Investigator seeks to evaluate the long term neurological and pulmonary sequelae of COVID-19.

  • 0 views
  • 24 Mar, 2022
  • 1 location