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Found 1368 clinical trials
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Cognitive Changes of IDH-mutant and IDH-wildtype Glioma Patients After Chemoradiotherapy With Radiation Dose to the Resting State Networks

most vulnerable and clinically relevant RSNs that correspond to cognitive decline. In this study, the investigators will prospectively perform RS-fMRI and neurocognitive evaluation using the NIH

astrocytoma
brain tumor
immunohistochemistry
karnofsky performance status
oligodendroglioma
  • 0 views
  • 10 Oct, 2021
  • 1 location
None
Sleep Aging and Risk for Alzheimer's 2.0

Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly. We will

positron emission tomography
obstructive sleep apnea
cognitive decline
polysomnography
amyloid
  • 303 views
  • 03 Feb, 2021
  • 1 location
None
Lung Function After Abdominal Surgery

after surgery. Inclusion: 30 patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies.

spirometry
abdominal operation
  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Longitudinal Innate Immunity and Aging Study

help us better understand what puts individuals at risk for cognitive decline and for Alzheimer's disease.

  • 74 views
  • 30 May, 2021
  • 1 location
None
Imaging of Brain Structural/Functional Connectivity and Amyloid and Tau Lesions in APOE4 Carriers.

(APOE4) gene that develop early vascular dysfunction and significant cerebrovascular pathology compared to non-carriers, and establish whether the neurovasculature plays a key role in cognitive decline

amyloid
flortaucipir
dementia
apolipoprotein e
cognitive decline
  • 0 views
  • 21 Oct, 2021
  • 1 location
None
Neurological Outcome After SARS-CoV-2 Infection

. Objectives: The investigators hypothesize that neurological manifestations and neuropsychological/cognitive deficits can be detected after COVID-19, substantially impact on patients' QoL and can be

  • 0 views
  • 01 Sep, 2021
  • 1 location
None
Neuroimaging and Neuropsychological Outcomes in Urea Cycle Disorders

deficiency); (ASLD) cognitive impairment and neuropsychiatric disease are common even in the absence of acute HA. As a consequence, both citrulline and argininosuccinate (ASA) or their metabolic products

brain pathology
encephalopathy
myo-inositol
citrulline
cognitive impairment
  • 75 views
  • 26 Apr, 2021
  • 1 location
None
A Neuropsychological Test Battery for the Assessment of Time Deficits

used for the assessment of cognitive deficits. Here we use Virtual Reality to study the ability to estimate time duration of an action execution and perception in a simulated everyday activity.

Accepts healthy volunteers
cognitive deficits
  • 0 views
  • 21 Oct, 2021
  • 1 location
None
Neurocognitive Impairment in Patients With COVID-19

highly valuable to detect and monitor cognitive impairment, especially with regard to limited resources available to perform time-consuming brain imaging. Biomarkers of neuroaxonal injury are

covid-19
cognitive impairment
SARS
  • 0 views
  • 10 Oct, 2021
  • 1 location
None
The Dutch Parkinson and Cognition Study

longitudinal cohort study aimed at deeply phenotyping newly diagnosed PD patients. The main aim is to investigate the relationship between cognitive impairment and both cholinergic and dopaminergic

neurodegenerative disorders
cognitive impairment
motor symptoms
  • 6 views
  • 23 Jan, 2021
  • 1 location