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Found 1267 clinical trials
Exploring Compensation to Maintain Cognitive Function in Adults Newly Diagnosed With Brain Cancer

Recent research indicates that variability in cognitive function for brain tumor survivors may be explained by differences in cognitive reserve (CR) and use of compensatory strategies.However, it is unknown when cognitive function declines or survivors tap into compensation. This longitudinal mixed methods study proposes to explore differences in cognitive function …

  • 16 Aug, 2021
  • 1 location
Renal Oxygen Saturation During Off-pump Coronary Artery Bypass Graft Surgery (OPCAB)

The purpose of this study is to evaluate changes in renal oxygen saturation (rrSO2) and its relationship with central venous oxygen saturation (cvSO2), cerebral cortical oxygen saturation (rcSO2), and hemodynamic parameters while displacing the heart for each coronary anastomosis in 19-80 year old adult patients receiving off-pump coronary artery bypass …

general anesthesia
  • 24 Mar, 2022
  • 1 location
Impact of Elastin Mediated Vascular Stiffness on End Organs

Background People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness. Blood vessels may have focal narrowings called stenoses or may just be globally more narrow. Objectives Researchers want to see how blood vessel differences in people …

supravalvular aortic stenosis
Accepts healthy volunteers
  • 12 May, 2022
  • 1 location
Metabolic Syndrome in Childhood Cancer Survivors

The research is devoted to studying the features of the metabolic syndrome in cancer survivors in childhood is supposed to answer the following questions: How can metabolic syndrome be diagnosed in the Russian population of survivors of acute lymphoblastic leukemia and non-Hodgkin's lymphomas? What are the features of the clinical …

  • 22 Jan, 2021
  • 1 location
Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)

The Swiss-Ped-IBrainD is a national patient registry that collects information on diagnosis, symptoms, treatment, and follow-up of pediatric patients with an inflammatory brain disease in Switzerland. It was first implemented in 2020 in the pediatric clinic of the university hospital in Bern. Further centers all over Switzerland were opened for …

acute disseminated encephalomyelitis
optic neuritis
encephalitis autoimmune
transverse myelitis
  • 01 Sep, 2021
  • 12 locations
Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases

Tau protein has been identified as one of the key pathological features of Tau proteinopathies, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD). Tau protein-targeted PET imaging can detect the amount and distribution of Tau protein deposition in human body, and has great research and application …

dementia, frontotemporal
screening procedures
tau protein
alzheimer's disease
  • 14 Mar, 2022
  • 1 location
Thinking Outside the Box

Medication adherence - the extent to which a patient takes their medications as prescribed - is a global problem. Half of all medicines given to patients with long-term health problems are not taken properly by the patient. Older adults are also more at risk of harm from their medications as …

  • 28 Jul, 2021
  • 1 location
Microbial Determinants of Dementia Risk in Type 2 Diabetics of Mexican Descent

Type 2 diabetes (T2D) predisposes individuals to neurodegeneration and dementia, including Alzheimer's Disease (AD); yet the link between metabolic and neurodegenerative disorders remains unknown. Here, the investigators will study a well-defined human population with increased prevalence and early onset of both T2D and AD, individuals of Mexican descent living in …

Accepts healthy volunteers
  • 16 Nov, 2021
  • 1 location
Self-motion Perception in Parkinson's Disease (SMP_PD)

Parkinson's Disease as well as being a disorder of motor function also causes a wide range of non-motor disturbances many of which are involved in the prodromal stage prior to the onset of motor symptoms. Abnormal perception in the visual and in other domains is increasingly being recognized. Control of …

motor symptoms
Accepts healthy volunteers
  • 13 Feb, 2022
  • 2 locations
The "MyoThrombus" Study

Left ventricular thrombus is a recognised complication of acute myocardial infarction, associated with stroke, recurrent myocardial infarction and adverse cardiac remodelling. The prevention, treatment and resolution of thrombus is hampered by a lack of understanding of its initiation, propagation and dissolution. Advanced non-invasive imaging holds major promise in improving our …

  • 24 Apr, 2021
  • 1 location