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Found 1270 clinical trials
Trajectories of Post-stroke Multidimensional Health

Stroke is thought to cause disability immediately after stroke followed by a 3-to-6-month recovery period, after which disability levels are supposed to stabilize unless recurrent events occur. However, studies showed that post-stroke recovery is heterogeneous. While some stroke survivors quickly recover, others may show an accelerated accumulation of disability over …

  • 05 Oct, 2021
  • 1 location
Study on Patients With Rasmussen Encephalitis Treated With Adalimumab: Efficacy and Tolerance in the Short and Long Term

Since the initial study of cases reported between 2009 and 2015, adalimumab has become in France the immunomodulatory reference treatment used after failure of corticosteroids and immunoglobulins before a possible recourse to the hemispherotomy. This observational study is intended to document the long-term efficacy and safety of Adalimumab therapy in …

  • 29 Aug, 2021
  • 1 location
Optimising the Care and Treatment Pathways for Older Patients Facing Major Gastrointestinal Surgery.

The UK population is ageing. Whilst many people remain active and in good health as they get older, getting older is associated with the onset of many common medical conditions, as well as memory and mobility problems. There is a natural decline in heart and lung fitness with age, although …

  • 28 Jan, 2021
  • 2 locations
Hepatic Urea Nitrogen Handling in Patients With NASH

The aim of the project is to investigate the metabolic regulation of the hepatic urea nitrogen handling and various cognitive functions measured by psychometric and neurophysiological tests before and after bariatric surgery in patients with non-alcoholic fatty liver disease (NAFLD).

bariatric surgery
liver disease
fatty liver
other liver diseases
  • 24 Jan, 2021
  • 1 location
Brain Functional MRI in Older Women With Breast Cancer (Brain fMRI-BC)

This study will use advanced MRI techniques to characterize the changes that occur to the structure and functionality of the brain in older breast cancer patients receiving adjuvant chemotherapy, and determine the relationship between the brain changes and severity of chemotherapy toxicity. Our results will be an early step towards …

adjuvant chemotherapy
  • 21 Mar, 2021
  • 2 locations
The Effect of CPAP Treatment on Cognitive Functions, Anxiety, and Affective Symptoms

Long term, prospective study of continuous positive airway pressure treatment influence on cognitive functions in patients with obstructive sleep apnea syndrome.

apnea-hypopnea index
continuous positive airway pressure
  • 24 Feb, 2022
  • 1 location
Pediatric Type 1 Diabetes and Neurocognitive Complications Cohort Study

The proposed project will assess hypothesized risk factors (age of onset, Diabetic ketoacidosis (DKA) at presentation and glycemic control), as well as potentially modifiable protective factors (child sleep quality, caregiver distress, and use of diabetes devices). In addition, the study will optimize imaging protocols and processing tools to allow for …

Accepts healthy volunteers
  • 25 Mar, 2022
  • 1 location
Neuroinflammation in Chronic Systemic Symptoms (CSS)

The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS).

  • 19 Sep, 2021
  • 1 location
Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis (ICROS)

Sepsis is a life-threatening condition which can affect people of any age. An infection triggers a host response resulting in organ failure. The extent of the organ dysfunction varies between patients and during the course of the condition. Thus far, the only causal treatment option consists in treating the infection …

antibiotic therapy
heart disease
  • 23 Apr, 2022
  • 1 location
Pervasive Sensing and AI in Intelligent ICU

Important information related to the visual assessment of patients, such as facial expressions, head and extremity movements, posture, and mobility are captured sporadically by overburdened nurses, or are not captured at all. Consequently, these important visual cues, although associated with critical indices such as physical functioning, pain, delirious state, and …

  • 25 Nov, 2021
  • 1 location