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Found 1243 clinical trials
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)

In this study, we will conduct retrospective chart and imaging reviews and prospective longitudinal virtual assessments of individuals with LBSL.

genetic analysis
  • 25 Jan, 2022
  • 1 location
The Effect of CPAP Treatment on Cognitive Functions Anxiety and Affective Symptoms

Long term, prospective study of continuous positive airway pressure treatment influence on cognitive functions in patients with obstructive sleep apnea syndrome.

apnea-hypopnea index
continuous positive airway pressure
  • 23 Jul, 2021
  • 1 location
Hepatic Urea Nitrogen Handling in Patients With NASH

The aim of the project is to investigate the metabolic regulation of the hepatic urea nitrogen handling and various cognitive functions measured by psychometric and neurophysiological tests before and after bariatric surgery in patients with non-alcoholic fatty liver disease (NAFLD).

liver disease
bariatric surgery
fatty liver
other liver diseases
  • 24 Jan, 2021
  • 1 location
Brain Functional MRI in Older Women With Breast Cancer (Brain fMRI-BC)

This study will use advanced MRI techniques to characterize the changes that occur to the structure and functionality of the brain in older breast cancer patients receiving adjuvant chemotherapy, and determine the relationship between the brain changes and severity of chemotherapy toxicity. Our results will be an early step towards …

adjuvant chemotherapy
  • 21 Mar, 2021
  • 2 locations
Neuroinflammation in Chronic Systemic Symptoms (CSS)

The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS).

  • 19 Sep, 2021
  • 1 location
Renal Oxygen Saturation During Off-pump Coronary Artery Bypass Graft Surgery

The purpose of this study is to evaluate changes in renal oxygen saturation (rrSO2) and its relationship with central venous oxygen saturation (cvSO2), cerebral cortical oxygen saturation (rcSO2), and hemodynamic parameters while displacing the heart for each coronary anastomosis in 19-80 year old adult patients receiving off-pump coronary artery bypass …

  • 26 Jan, 2021
  • 1 location
Associations of Carotid Plaque Characteristics With Brain Perfusion and Cognitive Function in Patients Undergoing CEA

Stroke is one of the leading causes of death and disability-adjusted life-years worldwide. Carotid high-risk atherosclerotic plaques are considered to be one of the major sources of ischemic stroke. The present study aimed to investigate the relationship of carotid plaque characteristics with brain perfusion and cognitive function in patients undergoing …

  • 18 Jul, 2021
  • 1 location
Exploring Compensation to Maintain Cognitive Function in Adults Newly Diagnosed With Brain Cancer

Recent research indicates that variability in cognitive function for brain tumor survivors may be explained by differences in cognitive reserve (CR) and use of compensatory strategies.However, it is unknown when cognitive function declines or survivors tap into compensation. This longitudinal mixed methods study proposes to explore differences in cognitive function …

  • 16 Aug, 2021
  • 1 location
Pervasive Sensing and AI in Intelligent ICU

Important information related to the visual assessment of patients, such as facial expressions, head and extremity movements, posture, and mobility are captured sporadically by overburdened nurses, or are not captured at all. Consequently, these important visual cues, although associated with critical indices such as physical functioning, pain, delirious state, and …

  • 25 Nov, 2021
  • 1 location
Pediatric Type 1 Diabetes and Neurocognitive Complications Cohort Study

The proposed project will assess hypothesized risk factors (age of onset, Diabetic ketoacidosis (DKA) at presentation and glycemic control), as well as potentially modifiable protective factors (child sleep quality, caregiver distress, and use of diabetes devices). In addition, the study will optimize imaging protocols and processing tools to allow for …

  • 03 Feb, 2021
  • 1 location