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Found 77 clinical trials
Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia

, other promising therapies that potentially work in synergy with hypothermia to improve neurologic outcomes need to be tested. One potential agent is melatonin. Melatonin is a naturally occurring

cytokines
hypothermia
encephalopathy
base deficit
free radical
  • 108 views
  • 02 Jun, 2022
  • 2 locations
Melatonin in Alzheimer's Disease: Effect on Disease Progression and Epileptiform Activity. (MADE)

This is a long-term, prospective, observational study to investigate and compare the levels and rhythm of melatonin in patients with AD dementia, mild cognitive impairment due to AD and healthy

cognitive impairment
electroencephalogram
alzheimer's disease
mild cognitive impairment
dementia
  • 7 views
  • 30 May, 2022
  • 1 location
Safety and Efficacy of Melatonin in Patients With Multiple Progressive Primary Sclerosis

Phase I / II randomized, single-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of melatonin administration combined with ocrelizumab in patients with Progressive

antioxidants
immunosuppressive agents
ocrelizumab
melatonin
  • 3 views
  • 21 Jul, 2022
  • 3 locations
Extended-Release Melatonin in Patients With Rapid Eye Movement Sleep Behavior Disorder

The purpose of this research is to compare the efficacy of immediate versus extended-release melatonin as a supplement affecting the sleep cycle in patients with Parkinson disease and Rapid Eye

  • 0 views
  • 03 Jun, 2022
  • 1 location
Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MelatoZincME)

The aim of the study is to investigate the effects of oral melatonin and zinc supplementation on core features in individuals with ME/CFS

encephalomyelitis
fatigue
melatonin
  • 0 views
  • 28 Jul, 2022
  • 1 location
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging

The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those

cognitive impairment
neuropsychological test
halcion
melatonin
dementia
  • 1 views
  • 15 Mar, 2022
  • 1 location
CLINICAL TRIAL ON A FOOD SUPPLEMENT WITH MELATONIN AND HERBAL PRODUCTS TO IMPROVE SLEEP QUALITY

A randomized, double-blind, placebo-controlled clinical trial on the ability of a dietary supplement containing melatonin and herbal products to improve sleep quality in subjects with insomnia

melatonin
insomnia
psychotherapeutic
sleep problem
Accepts healthy volunteers
  • 0 views
  • 29 Jul, 2022
  • 1 location
Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study

The purpose of the study is to evaluate the efficacy of exogenous melatonin in improving sleep quality in HD gene carriers.

chorea
change of medication
  • 12 views
  • 07 Jun, 2022
  • 1 location
Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk Symptoms

Randomized control trial assessing supplemental melatonin for youth with at-risk or psychotic symptoms.

psychotic symptoms
hallucinations
  • 119 views
  • 05 Apr, 2022
  • 1 location
Association Between Melatonin Use and Improved Sleep Quality After Total Knee Arthroplasty: A Randomized Control Trial

This randomized controlled trial (RCT) will compare the effects of melatonin vs. placebo in patients undergoing primary total knee arthroplasty (TKA). This RCT aims to study the effects

melatonin
poor sleep
Accepts healthy volunteers
  • 6 views
  • 15 Sep, 2022
  • 1 location