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Found 60 clinical trials
Phase I Study of APX005M in Pediatric CNS Tumors

This phase I trial studies the side effects and best dose of APX005M in treating younger patients with primary malignant central nervous system tumor that is growing, spreading, or getting worse (progressive), or newly diagnosed diffuse intrinsic pontine glioma. APX005M can trigger activation of B cells, monocytes, and dendritic cells …

filgrastim
dipg
hematopoietic stem cell transplantation
blood transfusion
apx005m
  • 167 views
  • 04 Oct, 2022
  • 11 locations
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease. Despite this terrible and frustrating outcome, continued treatment of this population remains fundamental to improving cure rates. Studying this relapsed population will help unearth clues to why conventional therapy …

filgrastim
ribociclib
medulloblastoma
trametinib
brain tumor
  • 231 views
  • 19 Apr, 2022
  • 1 location
A Phase 1 Study of Modified Measles Virus (MV-NIS) for the Treatment of Children and Young Adults With Recurrent Medulloblastoma or Recurrent Atypical Teratoid Rhabdoid Tumors (ATRT)

of the modified measles virus (MV-NIS) in children and young adults with recurrent medulloblastoma or atypical teratoid rhabdoid tumor (ATRT).

renal function
craniospinal irradiation
absolute neutrophil count
platelet count
nitrosoureas
  • 110 views
  • 25 Oct, 2022
  • 8 locations
NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors

The primary objective of this study is to evaluate the safety and clinical activity of NKG2D-based CAR-T cells infusion in the treatment of relapsed/refractory NKG2DL+ solid tumors.

metastasis
blood transfusion
liver metastasis
  • 0 views
  • 30 Nov, 2021
  • 1 location
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer

This phase I trial investigates the side effects and effectiveness of chemotherapy followed by a donor (allogeneic) stem cell transplant when given to patients with high grade brain cancer. Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte globulin, work in different ways to stop the growth of …

malignant glioma
medulloblastoma
cancer
ependymoma
brain tumor
  • 0 views
  • 04 Oct, 2022
  • 1 location
  • 0 views
  • 21 Oct, 2022
  • 1 location
Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients With Recurrent Select Rare CNS Cancers

Background More than 130 primary tumors of the central nervous system (CNS) have been identified. Most affect less than 1,000 people in the United States each year. Because these tumors are so rare, there are few proven therapies. This study will test whether the immunotherapy drug nivolumab is an effective …

cortisone
karnofsky performance status
medulloblastoma
meningioma
renal function
  • 120 views
  • 24 Oct, 2022
  • 11 locations
Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016)

This trial studies how well fimepinostat works in treating patients with newly diagnosed diffuse intrinsic pontine glioma, or medulloblastoma, or high-grade glioma that have come back

medulloblastoma
dexamethasone
brain tumor
anaplastic astrocytoma
malignant glioma
  • 3 views
  • 23 Jul, 2022
  • 21 locations
A Safety and Preliminary Efficacy Trial of Pembrolizumab (MK-3475) in Children With Recurrent, Progressive or Refractory Diffuse Intrinsic Pontine Glioma (DIPG), Non-Brainstem High-Grade Gliomas (NB-HGG), Ependymoma, Medulloblastoma or Hypermutated Brain Tumors

expected to be fast growing and aggressive), diffuse intrinsic pontine gliomas (brain stem tumors), brain tumors with a high number of genetic mutations, ependymoma or medulloblastoma that have come back

medulloblastoma
absolute neutrophil count
blood transfusion
tumor progression
sargramostim
  • 111 views
  • 11 Oct, 2022
  • 3 locations
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4 and CD8 T cells lentivirally transduced to express a HER2-specific chimeric antigen receptor (CAR) and EGFRt, delivered by an indwelling catheter in the tumor resection cavity or ventricular system in children and young …

immunohistochemistry
dexamethasone
cns disease
apheresis
HER2
  • 68 views
  • 17 Mar, 2022
  • 1 location