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Found 61 clinical trials
Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

medulloblastoma. Immune cells are part of the immune system and help the body fight infections and other diseases. Immune cells can be engineered to destroy brain tumor cells in the laboratory. IL13Ralpha2-CAR T

medulloblastoma
recurrent disease
tumor cells
brain tumor
immunohistochemistry
  • 0 views
  • 05 Apr, 2022
  • 1 location
131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma

A Phase 2 study investigating the addition of cRIT 131I-omburtamab to irinotecan, temozolomide, and bevacizumab for patients with recurrent medulloblastoma. A feasibility cohort is included to

  • 0 views
  • 07 Oct, 2022
  • 1 location
Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour (Met Med Can)

The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in children/adolescents treated for medulloblastoma will be investigated in a multi-site Phase III

  • 0 views
  • 07 Oct, 2022
  • 9 locations
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Patients will receive a vaccine called SurVaxM on this study. While vaccines are usually thought of as ways to prevent diseases, vaccines can also be used to treat cancer. SurVaxM is designed to tell the body's immune system to look for tumor cells that express a protein called survivin and …

medulloblastoma
tumor cells
dipg
cancer
sargramostim
  • 0 views
  • 07 Oct, 2022
  • 4 locations
Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

QARIN 1 is a study of [18F]DPA-714 Translocation Protein (TSPO) Positron Emission Tomography (PET) for longitudinal, quantitative assessment of brain neuroinflammation following whole brain radiation therapy. This TSPO PET, uses a radioactive tracer. An optional MRI (magnetic resonance imaging) will also be performed to monitor brain microstructure damages induced by …

medulloblastoma
MRI
  • 0 views
  • 04 Oct, 2022
  • 1 location
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma.

This clinical study is going to be done on a type of brain tumor in children called Medulloblastoma. The WNT pathway type of medulloblastoma is considered to be low risk and have the best

  • 0 views
  • 13 Oct, 2021
  • 1 location
Pilot Pharmacokinetic Study of VAL-413 (Orotecan®) in Patients With Recurrent Pediatric Solid Tumors

solid tumors including but not limited to neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, hepatoblastoma and medulloblastoma

medulloblastoma
nitrosoureas
cancer chemotherapy
cancer
central nervous system tumor
  • 13 views
  • 24 Oct, 2022
  • 1 location
Phase 2 Trial of Indoximod With Chemotherapy and Radiation for Children With Progressive Brain Tumors or Newly Diagnosed DIPG

progressive brain cancer (glioblastoma, medulloblastoma, or ependymoma), or newly-diagnosed diffuse intrinsic pontine glioma (DIPG). Statistical analysis will stratify patients based on whether their

aspart
dipg
initial diagnosis
lomustine
epilepsy
  • 0 views
  • 13 Oct, 2022
  • 3 locations
Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

25 years, with relapsed or refractory ependymoma, medulloblastoma/PNET, or glioblastoma that progressed after previous treatment with indoximod plus temozolomide. Those previously treated with

medulloblastoma
initial diagnosis
cancer
neutrophil count
tumor progression
  • 0 views
  • 23 Apr, 2022
  • 1 location
AflacST1901: Peds WP1066

In this Phase I clinical study, the investigators plan to offer investigational treatment with the novel JAK2/STAT3 inhibitor WP1066 (Moleculin Biotech, Inc.) to pediatric patients with any progressive or recurrent malignant brain tumor that is refractory to standard treatment and is without known cure.

medulloblastoma
antiepileptic
dipg
malignant glioma
tumor progression
  • 0 views
  • 04 Oct, 2022
  • 1 location